Prospective study of a serogroup X Neisseria meningitidis outbreak in northern Ghana

Details

Serval ID
serval:BIB_2CE0F474091A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Prospective study of a serogroup X Neisseria meningitidis outbreak in northern Ghana
Journal
Journal of Infectious Diseases
Author(s)
Gagneux  S. P., Hodgson  A., Smith  T. A., Wirth  T., Ehrhard  I., Morelli  G., Genton  B., Binka  F. N., Achtman  M., Pluschke  G.
ISSN
0022-1899 (Print)
Publication state
Published
Issued date
03/2002
Volume
185
Number
5
Pages
618-26
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 1
Abstract
After an epidemic of serogroup A meningococcal meningitis in northern Ghana, a gradual disappearance of the epidemic strain was observed in a series of five 6-month carriage surveys of 37 randomly selected households. As serogroup A Neisseria meningitidis carriage decreased, an epidemic of serogroup X meningococcal carriage occurred, which reached 18% (53/298) of the people sampled during the dry season of 2000, coinciding with an outbreak of serogroup X disease. These carriage patterns were unrelated to that of Neisseria lactamica. Multilocus sequence typing and pulsed-field gel electrophoresis of the serogroup X bacteria revealed strong similarity with other strains isolated in Africa during recent decades. Three closely related clusters with distinct patterns of spread were identified among the Ghanian isolates, and further microevolution occurred after they arrived in the district. The occurrence of serogroup X outbreaks argues for the inclusion of this serogroup into a multivalent conjugate vaccine against N. meningitidis.
Keywords
Adolescent Adult Carrier State/epidemiology/microbiology Child Child, Preschool *Disease Outbreaks Female Ghana/epidemiology Humans Incidence Male Meningitis, Meningococcal/*epidemiology/microbiology Neisseria meningitidis/*classification/genetics Prevalence Prospective Studies Serotyping
Pubmed
Web of science
Create date
28/01/2008 11:48
Last modification date
20/08/2019 13:11
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