Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis.
Journal of Molecular Endocrinology
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, initially described as molecular targets for synthetic compounds inducing peroxisome proliferation. PPAR-gamma, the best characterized of the PPARs, plays a crucial role in adipogenesis and insulin sensitization. Furthermore, PPAR-gamma has been reported to affect cell proliferation/differentiation pathways in various malignancies. We discuss in the present review recent advances in the understanding of the function of PPAR-gamma in both cell proliferation and adipocyte differentiation.
Adipose Tissue/cytology, Animals, Cell Differentiation/physiology, Cell Division/physiology, Cell Transformation, Neoplastic, Humans, Receptors, Cytoplasmic and Nuclear/physiology, Transcription Factors/physiology
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