Therapeutic drug monitoring of targeted anticancer protein kinase inhibitors in routine clinical use: A critical review.

Détails

ID Serval
serval:BIB_2BF80A005C57
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Therapeutic drug monitoring of targeted anticancer protein kinase inhibitors in routine clinical use: A critical review.
Périodique
Therapeutic drug monitoring
Auteur(s)
Cardoso E., Guidi M., Blanchet B., Schneider M.P., Decosterd L.A., Buclin T., Csajka C., Widmer N.
ISSN
1536-3694 (Electronic)
ISSN-L
0163-4356
Statut éditorial
Publié
Date de publication
02/2020
Peer-reviewed
Oui
Volume
42
Numéro
1
Pages
33-44
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Therapeutic response to oral targeted anticancer protein kinase inhibitors (PKIs) varies widely between patients, with insufficient efficacy of some of them and unacceptable adverse reactions of others. There are several possible causes for this heterogeneity, such as pharmacokinetic (PK) variability affecting blood concentrations, fluctuating medication adherence, and constitutional or acquired drug resistance of cancer cells. The appropriate management of oncology patients with PKI treatments thus requires concerted efforts to optimize the utilization of these drug agents, which have probably not yet revealed their full potential.
An extensive literature review was performed on MEDLINE on the PK, pharmacodynamics, and therapeutic drug monitoring (TDM) of PKIs (up to April 2019).
This review provides the criteria for determining PKIs suitable candidates for TDM (eg, availability of analytical methods, observational PK studies, PK-pharmacodynamics relationship analysis, and randomized controlled studies). It reviews the major characteristics and limitations of PKIs, the expected benefits of TDM for cancer patients receiving them, and the prerequisites for the appropriate utilization of TDM. Finally, it discusses various important practical aspects and pitfalls of TDM for supporting better implementation in the field of cancer treatment.
Adaptation of PKIs dosage regimens at the individual patient level, through a rational TDM approach, could prevent oncology patients from being exposed to ineffective or unnecessarily toxic drug concentrations in the era of personalized medicine.
Pubmed
Création de la notice
10/09/2019 9:05
Dernière modification de la notice
12/01/2020 6:20
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