Fatal Outcome of Multiple Clinical Presentations of Human Herpesvirus 8-related Disease After Solid Organ Transplantation.

Détails

ID Serval
serval:BIB_2BE89E653468
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Fatal Outcome of Multiple Clinical Presentations of Human Herpesvirus 8-related Disease After Solid Organ Transplantation.
Périodique
Transplantation
Auteur(s)
Vijgen S., Wyss C., Meylan P., Bisig B., Letovanec I., Manuel O., Pascual M., de Leval L.
ISSN
1534-6080 (Electronic)
ISSN-L
0041-1337
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
100
Numéro
1
Pages
134-140
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article Publication Status: ppublish
Résumé
Kaposi sarcoma is the most common human herpesvirus 8 (HHV-8)-related disease described after solid organ transplantation. Multicentric Castleman disease and hemophagocytic syndrome are other potential HHV-8-induced entities but are less frequently reported. We describe the case of a liver transplant recipient who presented with an acute febrile illness 1 year after transplantation with a rapidly fatal outcome. Autopsy revealed 3 distinct HHV-8-related entities: Kaposi sarcoma, HHV-8-associated multicentric Castleman disease with microlymphomas and a severe hemophagocytic syndrome. Retrospective serologic tests suggested that HHV-8 was likely transmitted by the seropositive donor at the time of transplantation. To our knowledge, this is the first case of copresentation of 3 clinical presentations of HHV-8-mediated human disease in the post-transplant setting. Considering the absence of systematic screening of organ donors/recipients for HHV-8 infection, HHV-8-related illness should be suspected in transplant recipients who present with acute febrile illness, systemic symptoms, lymphadenopathies, and/or multiorgan failure to rapidly document the diagnosis and provide timely an adequate treatment.
Mots-clé
Aged, Autopsy, Biopsy, Carcinoma, Hepatocellular/diagnosis, Carcinoma, Hepatocellular/etiology, Cause of Death, Fatal Outcome, Giant Lymph Node Hyperplasia/diagnosis, Giant Lymph Node Hyperplasia/virology, Herpesviridae Infections/diagnosis, Herpesviridae Infections/transmission, Herpesvirus 8, Human/pathogenicity, Humans, Liver Diseases, Alcoholic/diagnosis, Liver Diseases, Alcoholic/etiology, Liver Neoplasms/diagnosis, Liver Neoplasms/etiology, Liver Transplantation/adverse effects, Lymphohistiocytosis, Hemophagocytic/diagnosis, Lymphohistiocytosis, Hemophagocytic/virology, Male, Middle Aged, Sarcoma, Kaposi/diagnosis, Sarcoma, Kaposi/virology, Serologic Tests, Time Factors, Treatment Outcome
Pubmed
Web of science
Création de la notice
30/06/2015 13:03
Dernière modification de la notice
20/08/2019 13:11
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