Article: article from journal or magazin.
Fatal Outcome of Multiple Clinical Presentations of Human Herpesvirus 8-related Disease After Solid Organ Transplantation.
Publication types: Case Reports ; Journal Article Publication Status: ppublish
Kaposi sarcoma is the most common human herpesvirus 8 (HHV-8)-related disease described after solid organ transplantation. Multicentric Castleman disease and hemophagocytic syndrome are other potential HHV-8-induced entities but are less frequently reported. We describe the case of a liver transplant recipient who presented with an acute febrile illness 1 year after transplantation with a rapidly fatal outcome. Autopsy revealed 3 distinct HHV-8-related entities: Kaposi sarcoma, HHV-8-associated multicentric Castleman disease with microlymphomas and a severe hemophagocytic syndrome. Retrospective serologic tests suggested that HHV-8 was likely transmitted by the seropositive donor at the time of transplantation. To our knowledge, this is the first case of copresentation of 3 clinical presentations of HHV-8-mediated human disease in the post-transplant setting. Considering the absence of systematic screening of organ donors/recipients for HHV-8 infection, HHV-8-related illness should be suspected in transplant recipients who present with acute febrile illness, systemic symptoms, lymphadenopathies, and/or multiorgan failure to rapidly document the diagnosis and provide timely an adequate treatment.
Aged, Autopsy, Biopsy, Carcinoma, Hepatocellular/diagnosis, Carcinoma, Hepatocellular/etiology, Cause of Death, Fatal Outcome, Giant Lymph Node Hyperplasia/diagnosis, Giant Lymph Node Hyperplasia/virology, Herpesviridae Infections/diagnosis, Herpesviridae Infections/transmission, Herpesvirus 8, Human/pathogenicity, Humans, Liver Diseases, Alcoholic/diagnosis, Liver Diseases, Alcoholic/etiology, Liver Neoplasms/diagnosis, Liver Neoplasms/etiology, Liver Transplantation/adverse effects, Lymphohistiocytosis, Hemophagocytic/diagnosis, Lymphohistiocytosis, Hemophagocytic/virology, Male, Middle Aged, Sarcoma, Kaposi/diagnosis, Sarcoma, Kaposi/virology, Serologic Tests, Time Factors, Treatment Outcome
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