Article: article from journal or magazin.
High antigen concentration inhibits T cell proliferation but not interleukin 2 production: examination of limiting dilution microcultures and T cell clones.
European Journal of Immunology
The effect of high antigen dose on the activation of cytochrome c peptide-primed lymph node cells was determined in several strains of mice by a limiting dilution analysis. It was found that proliferation of cytochrome c peptide-specific T cells was completely inhibited at high antigen concentration in C57BL/6 but only partially in DBA mice and had no effect in SJL mice. Clones derived from DBA mice showed a differential capacity to be inhibited by high antigen dose. On the other hand, interleukin 2 production by these clones was not impaired regardless of the antigen concentrations used.
Animals, Clone Cells, Cytochrome c Group/immunology, Dose-Response Relationship, Immunologic, Female, Interleukin-2/biosynthesis, Lymph Nodes/immunology, Lymphocyte Activation, Mice, Mice, Inbred Strains, T-Lymphocytes/immunology, T-Lymphocytes/metabolism
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