High antigen concentration inhibits T cell proliferation but not interleukin 2 production: examination of limiting dilution microcultures and T cell clones.
Details
Serval ID
serval:BIB_2BD8F8D7BFE9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
High antigen concentration inhibits T cell proliferation but not interleukin 2 production: examination of limiting dilution microcultures and T cell clones.
Journal
European Journal of Immunology
ISSN
0014-2980 (Print)
ISSN-L
0014-2980
Publication state
Published
Issued date
1986
Volume
16
Number
1
Pages
30-34
Language
english
Abstract
The effect of high antigen dose on the activation of cytochrome c peptide-primed lymph node cells was determined in several strains of mice by a limiting dilution analysis. It was found that proliferation of cytochrome c peptide-specific T cells was completely inhibited at high antigen concentration in C57BL/6 but only partially in DBA mice and had no effect in SJL mice. Clones derived from DBA mice showed a differential capacity to be inhibited by high antigen dose. On the other hand, interleukin 2 production by these clones was not impaired regardless of the antigen concentrations used.
Keywords
Animals, Clone Cells, Cytochrome c Group/immunology, Dose-Response Relationship, Immunologic, Female, Interleukin-2/biosynthesis, Lymph Nodes/immunology, Lymphocyte Activation, Mice, Mice, Inbred Strains, T-Lymphocytes/immunology, T-Lymphocytes/metabolism
Pubmed
Web of science
Create date
24/01/2008 15:55
Last modification date
20/08/2019 14:11
Usage data
