Perivascular Fibroblasts of the Developing Spleen Act as LTα1β2-Dependent Precursors of Both T and B Zone Organizer Cells.

Détails

Ressource 1Télécharger: 1-s2.0-S2211124717315991-main.pdf (6590.05 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_2BD5BF80996B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Perivascular Fibroblasts of the Developing Spleen Act as LTα1β2-Dependent Precursors of Both T and B Zone Organizer Cells.
Périodique
Cell reports
Auteur(s)
Schaeuble K., Britschgi M.R., Scarpellino L., Favre S., Xu Y., Koroleva E., Lissandrin TKA, Link A., Matloubian M., Ware C.F., Nedospasov S.A., Tumanov A.V., Cyster J.G., Luther S.A.
ISSN
2211-1247 (Electronic)
Statut éditorial
Publié
Date de publication
28/11/2017
Peer-reviewed
Oui
Volume
21
Numéro
9
Pages
2500-2514
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
T and B cell compartmentalization is a hallmark of secondary lymphoid organs and is maintained by chemokine-expressing stromal cells. How this stromal cell network initially develops and differentiates into two distinct subsets is poorly known, especially for the splenic white pulp (WP). Here, we show that perivascular fibroblast precursors are triggered by LTα1β2 signals to expand, express CCL19/21, and then differentiate into two functionally distinct fibroblast subsets responsible for B and T cell clustering and WP compartmentalization. Failure to express or sense CCL19 leads to impaired T zone development, while lack of B cells or LTα1β2 leads to an earlier and stronger impairment in WP development. We therefore propose that WP development proceeds in multiple steps, with LTα1β2 <sup>+</sup> B cells acting as major inducer cells driving the expansion and gradual differentiation of perivascular fibroblasts into T and B zone organizer cells.
Mots-clé
Animals, Cell Differentiation/physiology, Chemokine CCL19/metabolism, Chemokine CXCL13/metabolism, Chemokines, CXC/metabolism, Fibroblasts/metabolism, Fibroblasts/physiology, Lymphotoxin-alpha/metabolism, Mice, Spleen/cytology, Spleen/metabolism, CCR7, CXCL13, ILC3, LTi cells, PALS, chemokines, fibroblast heterogeneity, lymphocytes, lymphotoxin, stroma
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/12/2017 10:59
Dernière modification de la notice
08/05/2019 16:22
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