Risperidone-induced symptomatic hyperprolactinaemia in adolescents.

Détails

ID Serval
serval:BIB_2BC65C3A1135
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Risperidone-induced symptomatic hyperprolactinaemia in adolescents.
Périodique
Journal of clinical psychopharmacology
Auteur(s)
Holzer L., Eap C.B.
ISSN
0271-0749
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
26
Numéro
2
Pages
167-171
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article - Publication Status: ppublish
Résumé
Studies performed in adult patients unambiguously demonstrate a marked effect of risperidone on prolactin blood levels, with possible clinical effects related to hyperprolactinemia, such as gynecomastia and galactorrhea. However, the largest study performed in children and adolescents showed a weak effect of risperidone on prolactin concentrations during short-term treatment and a negligible effect during long-term treatment, which was probably because of the relatively low dosages of risperidone used [approximately 0.04 mg/(kg x d)]. Among the 10 psychotic adolescents treated with risperidone in our unit, we had 3 cases of gynecomastia in 3 male patients and 2 cases of galactorrhea in 2 female patients. The prolactin blood levels in these cases and in 3 other patients without apparent prolactin-related side effects were all above the normal range (median, 59 ng/mL; range, 30-123 ng/mL). Thus, risperidone administered to adolescents at doses commonly used for the treatment of psychotic symptoms can strongly increase prolactin levels, with clinical consequences such as gynecomastia and/or galactorrhea. Given that the long-term effects of antipsychotic drug-induced hyperprolactinemia are not well documented, especially regarding osteopenia, infertility, growth, and pubertal delay, risperidone should be administered with caution to children and adolescents.
Mots-clé
Adolescent, Antipsychotic Agents, Drug Monitoring, Female, Galactorrhea, Gynecomastia, Humans, Hyperprolactinemia, Male, Prolactin, Psychotic Disorders, Risperidone
Pubmed
Web of science
Création de la notice
10/03/2008 11:53
Dernière modification de la notice
03/03/2018 15:25
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