Predictors and Outcomes of Recurrent Venous Thromboembolism in Elderly Patients.

Détails

ID Serval
serval:BIB_2BB68D2B9613
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Predictors and Outcomes of Recurrent Venous Thromboembolism in Elderly Patients.
Périodique
The American journal of medicine
Auteur(s)
Lauber S., Limacher A., Tritschler T., Stalder O., Méan M., Righini M., Aschwanden M., Beer J.H., Frauchiger B., Osterwalder J., Kucher N., Lämmle B., Cornuz J., Angelillo-Scherrer A., Matter C.M., Husmann M., Banyai M., Staub D., Mazzolai L., Hugli O., Rodondi N., Aujesky D.
ISSN
1555-7162 (Electronic)
ISSN-L
0002-9343
Statut éditorial
Publié
Date de publication
06/2018
Peer-reviewed
Oui
Volume
131
Numéro
6
Pages
703.e7-703.e16
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Little is known about predictors and outcomes of recurrent venous thromboembolism in elderly patients.
We prospectively followed up 991 patients aged ≥65 years with acute venous thromboembolism in a multicenter Swiss cohort study. The primary outcome was symptomatic recurrent venous thromboembolism. We explored the association between baseline characteristics and treatments and recurrent venous thromboembolism using competing risk regression, adjusting for periods of anticoagulation as a time-varying covariate. We also assessed the clinical consequences (case-fatality, localization) of recurrent venous thromboembolism.
During a median follow-up period of 30 months, 122 patients developed recurrent venous thromboembolism, corresponding to a 3-year cumulative incidence of 14.8%. The case-fatality of recurrence was high (20.5%), particularly in patients with unprovoked (23%) and cancer-related venous thromboembolism (29%). After adjustment, only unprovoked venous thromboembolism (sub-hazard ratio, 1.67 compared with provoked venous thromboembolism; 95% confidence interval, 1.00-2.77) and proximal deep vein thrombosis (sub-hazard ratio, 2.41 compared with isolated distal deep vein thrombosis; 95% confidence interval, 1.07-5.38) were significantly associated with recurrence. Patients with initial pulmonary embolism were more likely to have another pulmonary embolism as a recurrent event than patients with deep vein thrombosis.
Elderly patients with acute venous thromboembolism have a substantial long-term risk of recurrent venous thromboembolism, and recurrence carries a high case-fatality rate. Only 2 factors, unprovoked venous thromboembolism and proximal deep vein thrombosis, were independently associated with recurrent venous thromboembolism, indicating that traditional risk factors for venous thromboembolism recurrence (eg, cancer) may be less relevant in the elderly.
Mots-clé
Elderly, Recurrence, Venous thromboembolism
Pubmed
Web of science
Création de la notice
22/01/2018 11:24
Dernière modification de la notice
16/10/2019 16:15
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