Hemofiltration clearance of flecainide in a patient with acute renal failure

Details

Serval ID
serval:BIB_2BB6202C2205
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Hemofiltration clearance of flecainide in a patient with acute renal failure
Journal
Intensive Care Medicine
Author(s)
Borgeat  A., Biollaz  J., Freymond  B., Bayer-Berger  M., Chiolero  R.
ISSN
0342-4642 (Print)
Publication state
Published
Issued date
1988
Volume
14
Number
3
Pages
236-7
Notes
Case Reports
Journal Article
Abstract
Flecainide, a new antiarrhythmic drug, has been shown not no be removed to a significant extent by hemodialysis or peritoneal dialysis, in spite of a high renal clearance. Its systemic and hemofiltrate clearances, measured in a patient under continuous hemofiltration, were 402 and 19.7 ml/min respectively. The clearance ratio of less than 5% makes the contribution of hemofiltration to the elimination of flecainide clinically negligible.
Keywords
*Flecainide/administration & dosage/pharmacokinetics *Hemofiltration Humans Kidney Failure, Acute/*therapy Male Middle Aged
Pubmed
Web of science
Create date
25/01/2008 10:41
Last modification date
20/08/2019 13:11
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