Evolving characteristics and outcome of secondary acute promyelocytic leukemia (APL): A prospective analysis by the French-Belgian-Swiss APL group.

Détails

ID Serval
serval:BIB_2BB0B5A543B4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evolving characteristics and outcome of secondary acute promyelocytic leukemia (APL): A prospective analysis by the French-Belgian-Swiss APL group.
Périodique
Cancer
Auteur(s)
Braun T., Cereja S., Chevret S., Raffoux E., Beaumont M., Detourmignies L., Pigneux A., Thomas X., Bordessoule D., Guerci A., Lamy T., Recher C., Poiré X., Tournilhac O., Spertini O., Chomienne C., Degos L., Dombret H., Adès L., Fenaux P.
Collaborateur(s)
French-Belgian-Swiss APL Group
ISSN
1097-0142 (Electronic)
ISSN-L
0008-543X
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
121
Numéro
14
Pages
2393-2399
Langue
anglais
Résumé
BACKGROUND: Reports of patients with secondary acute promyelocytic leukemia (APL) have increased in recent years, particularly for those who received treatment with mitoxantrone, and retrospective studies have suggested that their characteristics and outcomes were similar to those of patients with de novo APL.
METHODS: The authors investigated patients with de novo and secondary APL who were included in the ongoing APL-2006 trial. Patients with secondary APL who were included in that trial also were compared with a previous retrospective cohort of patients with secondary APL.
RESULTS: In the APL-2006 trial, 42 of 280 patients (15%) had secondary APL. Compared with the retrospective cohort, patients with secondary APL in the APL-2006 trial had a lower incidence of prior breast carcinoma (35.7% vs 57%; P = .03) and a higher incidence of prior prostate carcinoma (26.2% vs 4.7%; P < .001). Treatment of the primary tumor in the APL-2006 trial less frequently included combined radiochemotherapy (28.6% vs 47.2%; P = .044) and no mitoxantrone (0% vs 46.7%; P = .016) but more frequently included anthracyclines (53.3% vs 38.3%; P = .015). In the APL-2006 trial, patients who had secondary APL, compared with those who had de novo APL, were older (mean, 60.2 years vs 48.7 years, respectively; P < .0001) but had a similar complete response rate (97.6% vs 90.3%, respectively), cumulative incidence of relapse (0% vs 1.8%, respectively), and overall survival (92.3% vs 90.9%, respectively) at 18 months.
CONCLUSIONS: Although the incidence of secondary APL appears to be stable over time, evolving strategies for the treatment of primary cancers have reduced its occurrence among breast cancer patients but have increased its incidence among patients with prostate cancer. The current results confirm prospectively that patients with secondary APL have characteristics and outcomes similar to those of patients with de novo APL. Cancer 2015;121:2393-2399. © 2015 American Cancer Society.
Pubmed
Web of science
Création de la notice
01/08/2015 9:44
Dernière modification de la notice
03/03/2018 15:25
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