Common skin infection due to Panton-Valentine leucocidin-producing Staphylococcus aureus strains in asylum seekers from Eritrea: a genome-based investigation of a suspected outbreak.

Détails

Ressource 1Télécharger: 1-s2.0-S1198743X16301781-main.pdf (702.71 [Ko])
Etat: Serval
Version: Final published version
ID Serval
serval:BIB_2B92A831F5B5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Common skin infection due to Panton-Valentine leucocidin-producing Staphylococcus aureus strains in asylum seekers from Eritrea: a genome-based investigation of a suspected outbreak.
Périodique
Clinical microbiology and infection
Auteur(s)
Jaton L., Pillonel T., Jaton K., Dory E., Prod'hom G., Blanc D.S., Tissot F., Bodenmann P., Greub G.
ISSN
1469-0691 (Electronic)
ISSN-L
1198-743X
Statut éditorial
Publié
Date de publication
08/2016
Peer-reviewed
Oui
Volume
22
Numéro
8
Pages
739.e5-8
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Since late 2014, multiple cases of abscesses and boils due to methicillin-susceptible Staphylococcus aureus (MSSA) expressing the Panton-Valentine leucocidin (PVL) were observed in Eritrean asylum seekers in Lausanne, Switzerland. Strains isolated from infected Eritrean and non-Eritrean patients were compared by whole genome sequencing to determine whether these numerous cases result from an outbreak. The genome of S. aureus PVL-producing strains were sequenced and compared. Clinical and epidemiological characteristics of patients infected by PVL-producing strains were investigated. This work reports 15 cases of infections due to PVL-producing strains affecting mostly asylum seekers (n = 10), people working with refugees and/or exposed to Africans (n = 3). Most infections were due to closely related strains of CC152 (n = 8) and CC15 (n = 3), two distantly related (>34 000 core single nucleotide polymorphisms) clonal complexes. An epidemiological link between the 15 cases could be ruled out by whole genome sequencing (33 to 172 core single nucleotide polymorphisms between the different strains of a given complex). Altogether, these results reflect the probable high incidence of CC15 and CC152 PVL-producing strains in eastern Africa. Clinicians facing unusual skin infections in African refugees (or in any person returning from this region of high endemicity) should consider S. aureus PVL-producer before suspecting rare infections such as leishmaniasis or rickettsiosis. Clinicians should also remember that PVL are frequently expressed by MSSA in some regions of the world and that antibiotics that are efficient on toxin expression, such as clindamycin, represent the best therapeutic option.

Mots-clé
Adolescent, Adult, Bacterial Toxins/biosynthesis, Bacterial Toxins/genetics, Child, Child, Preschool, Disease Outbreaks, Eritrea/epidemiology, Exotoxins/biosynthesis, Exotoxins/genetics, Female, Genome, Bacterial, Genomics, Humans, Leukocidins/biosynthesis, Leukocidins/genetics, Male, Middle Aged, Phylogeny, Polymorphism, Single Nucleotide, Refugees, Staphylococcal Skin Infections/epidemiology, Staphylococcal Skin Infections/microbiology, Staphylococcus aureus/classification, Staphylococcus aureus/genetics, Young Adult
Pubmed
Open Access
Oui
Création de la notice
18/06/2016 18:26
Dernière modification de la notice
08/05/2019 16:21
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