Benign hepatocellular nodules: what have we learned using the patho-molecular classification.

Détails

ID Serval
serval:BIB_2B7F63626757
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Benign hepatocellular nodules: what have we learned using the patho-molecular classification.
Périodique
Clinics and Research in Hepatology and Gastroenterology
Auteur(s)
Sempoux C., Chang C., Gouw A., Chiche L., Zucman-Rossi J., Balabaud C., Bioulac-Sage P.
ISSN
2210-741X (Electronic)
ISSN-L
2210-7401
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
37
Numéro
4
Pages
322-327
Langue
anglais
Notes
Publication types: Journal Article ; Review Publication Status: ppublish
Résumé
Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are benign hepatocellular tumors that develop most frequently in females and in non-cirrhotic livers. HCA are prone to bleed and to transform into hepatocellular carcinoma (HCC). Four major subgroups of HCA have been thus far identified: HNF1α mutated HCA, inflammatory HCA (IHCA), β-catenin mutated HCA (b-HCA and b-IHCA), based on mutations in specific oncogenes and tumor suppressors. B-HCA and b-IHCA are strongly associated with HCC transformation. Benign hepatocellular tumors can be classified using immunohistochemistry (LFABP, CRP, GS, b-catenin). Analysis of HCA phenotypes has led to the identification of patients at risk of HCC transformation and therefore improved the indications provided by invasive and non-invasive diagnostic techniques, such as biopsies and MRI. These recent advances have broadened the clinical scope of HCA in various conditions, such as their presence in males, in obese patients, in patients suffering from liver vascular disorders, genetic diseases. However, specific immunohistochemistry has shown limitations particularly for the identification of b-HCA, thereby, outlining the importance of molecular studies to improve the diagnosis/prognosis of HCA. If evaluation of prognosis and treatment has benefited from these advances, much more needs to be done to obtain guidelines for good clinical practice.
Mots-clé
Adenoma, Liver Cell/classification, Adenoma, Liver Cell/pathology, Humans
Pubmed
Web of science
Création de la notice
19/01/2015 12:14
Dernière modification de la notice
03/10/2018 15:42
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