Quantification of in vivo short echo-time proton magnetic resonance spectra at 14.1 T using two different approaches of modelling the macromolecule spectrum

Détails

ID Serval
serval:BIB_2B1C0FE71B41
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Quantification of in vivo short echo-time proton magnetic resonance spectra at 14.1 T using two different approaches of modelling the macromolecule spectrum
Périodique
Measurement Science and Technology
Auteur(s)
Cudalbu C., Mlynarik V., Xin L., Gruetter R.
ISSN
0957-0233
Statut éditorial
Publié
Date de publication
2009
Volume
20
Numéro
10
Pages
104034
Langue
anglais
Résumé
Reliable quantification of the macromolecule signals in short echo-time H-1 MRS spectra is particularly important at high magnetic fields for an accurate quantification of metabolite concentrations (the neurochemical profile) due to effectively increased spectral resolution of the macromolecule components. The purpose of the present study was to assess two approaches of quantification, which take the contribution of macromolecules into account in the quantification step. H-1 spectra were acquired on a 14.1 T/26 cm horizontal scanner on five rats using the ultra-short echo-time SPECIAL (spin echo full intensity acquired localization) spectroscopy sequence. Metabolite concentrations were estimated using LCModel, combined with a simulated basis set of metabolites using published spectral parameters and either the spectrum of macromolecules measured in vivo, using an inversion recovery technique, or baseline simulated by the built-in spline function. The fitted spline function resulted in a smooth approximation of the in vivo macromolecules, but in accordance with previous studies using Subtract-QUEST could not reproduce completely all features of the in vivo spectrum of macromolecules at 14.1 T. As a consequence, the measured macromolecular 'baseline' led to a more accurate and reliable quantification at higher field strengths.
Mots-clé
in vivo short echo-time H-1 MRS, quantification of neurochemical profile, macromolecule contribution, Localized H-1 Mrs, Rat-Brain, Neurochemical Profile, H-1-Nmr Spectroscopy, Metabolite Concentrations, Background-Accommodation, Base-Line, Signals, Quantitation, Tesla
Web of science
Création de la notice
07/10/2009 17:10
Dernière modification de la notice
03/03/2018 15:24
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