Direct, noninvasive measurement of brain glycogen metabolism in humans.

Détails

ID Serval
serval:BIB_2B0010762526
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Direct, noninvasive measurement of brain glycogen metabolism in humans.
Périodique
Neurochemistry International
Auteur(s)
Oz G., Henry P.G., Seaquist E.R., Gruetter R.
ISSN
0197-0186 (Print)
ISSN-L
0197-0186
Statut éditorial
Publié
Date de publication
2003
Volume
43
Numéro
4-5
Pages
323-329
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Résumé
The concentration and metabolism of the primary carbohydrate store in the brain, glycogen, is unknown in the conscious human brain. This study reports the first direct detection and measurement of glycogen metabolism in the human brain, which was achieved using localized 13C NMR spectroscopy. To enhance the NMR signal, the isotopic enrichment of the glucosyl moieties was increased by administration of 80 g of 99% enriched [1-13C]glucose in four subjects. 3 h after the start of the label administration, the 13C NMR signal of brain glycogen C1 was detected (0.36+/-0.07 micromol/g, mean+/-S.D., n=4). Based on the rate of 13C label incorporation into glycogen and the isotopic enrichment of plasma glucose, the flux through glycogen synthase was estimated at 0.17+/-0.05 micromol/(gh). This study establishes that brain glycogen can be measured in humans and indicates that its metabolism is very slow in the conscious human. The noninvasive detection of human brain glycogen opens the prospect of understanding the role and function of this important energy reserve under various physiological and pathophysiological conditions.
Mots-clé
Adult, Blood Glucose/metabolism, Brain/metabolism, Glycogen/metabolism, Humans, Magnetic Resonance Spectroscopy, Male
Pubmed
Web of science
Création de la notice
04/08/2010 16:28
Dernière modification de la notice
03/03/2018 15:24
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