Connexin implication in the control of the murine beta-cell mass.

Détails

ID Serval
serval:BIB_2A6CA1B1D2E5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Connexin implication in the control of the murine beta-cell mass.
Périodique
Pediatric Research
Auteur(s)
Klee P., Lamprianou S., Charollais A., Caille D., Sarro R., Cederroth M., Haefliger J.A., Meda P.
ISSN
1530-0447 (Electronic)
ISSN-L
0031-3998
Statut éditorial
Publié
Date de publication
2011
Volume
70
Numéro
2
Pages
142-147
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Diabetes develops when the insulin needs of peripheral cells exceed the availability or action of the hormone. This situation results from the death of most beta-cells in type 1 diabetes, and from an inability of the beta-cell mass to adapt to increasing insulin needs in type 2 and gestational diabetes. We analyzed several lines of transgenic mice and showed that connexins (Cxs), the transmembrane proteins that form gap junctions, are implicated in the modulation of the beta-cell mass. Specifically, we found that the native Cx36 does not alter islet size or insulin content, whereas the Cx43 isoform increases both parameters, and Cx32 has a similar effect only when combined with GH. These findings open interesting perspectives for the in vitro and in vivo regulation of the beta-cell mass.
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/10/2011 17:35
Dernière modification de la notice
08/05/2019 16:16
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