Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Degenerescence programmee de maladies musculaires: aspects moleculaires et previsions therapeutiques. [Mechanisms leading to muscle degeneration: molecular mechanisms and therapeutical forecasts]
Revue Médicale Suisse
English Abstract Journal Article Review --- Old month value: May 3
In inclusion body myositis (IBM), there is muscular amyloidogenesis and inflammation. A related disorder is due to alterations in the ubiquitin pathway involving the valsolin-containing protein leading to IBM, dementia and Paget's disease. Alteration in the dystrophin glycoprotein complex leads to several muscular dystrophies (MD), and the pathogenesis of dystrophin related MD as well as certain limb girdle MD are discussed. Therapeutic strategies involving inhibition of proteolytic cascades as well as inhibition of a negative regulator of muscle growth (myostatin) are briefly introduced. Finally, molecular aspects of the most common form of adult myopathy, myotonic MD, are discussed. This disease is caused by an aberrant splicing mechanism and interference thereof may be useful in designing therapeutic strategies.
Humans Muscular Dystrophies/*drug therapy/*genetics Myositis, Inclusion Body/*drug therapy/*genetics
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