Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values.
Details
Serval ID
serval:BIB_2A2D49B94C9B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values.
Journal
Journal of Computer Assisted Tomography
ISSN
0363-8715 (Print)
ISSN-L
0363-8715
Publication state
Published
Issued date
1980
Volume
4
Number
6
Pages
727-736
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
A method is described for quantifying regional cerebral blood flow (rCBF), oxygen extraction (rOER), and oxygen utilization (rCMRO2) in man non-invasively, using inhaled 15O-labeled CO2 and O2 and positron emission tomography. The theoretical considerations and practical aspects are described. The results of rCBF, rCMRO2, and rOER for gray and white matter in normal volunteers are presented. The significance and limitations of the results are discussed. The method appears suitable for the study of human cerebral aerobic metabolism and blood flow under differing physiological conditions and in a wide variety of neurological disorders.
Keywords
Adult, Aged, Cerebrovascular Circulation, Dose-Response Relationship, Radiation, Female, Humans, Male, Mathematics, Middle Aged, Oxygen Consumption, Oxygen Radioisotopes/diagnostic use, Regional Blood Flow, Tomography, Emission-Computed
Pubmed
Web of science
Create date
09/10/2011 19:44
Last modification date
20/08/2019 14:09
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