Newly described pattern recognition receptors team up against intracellular pathogens.

Détails

ID Serval
serval:BIB_2A2740B42BE8
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Newly described pattern recognition receptors team up against intracellular pathogens.
Périodique
Nature Reviews. Immunology
Auteur(s)
Broz P., Monack D.M.
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
13
Numéro
8
Pages
551-565
Langue
anglais
Résumé
Recognizing the presence of invading pathogens is key to mounting an effective innate immune response. Mammalian cells express different classes of germline-encoded pattern recognition receptors that monitor the extracellular and intracellular compartments of host cells for signs of infection and that activate several conserved signalling pathways. An efficient immune response often requires the sequential detection of a pathogen by different receptors in different subcellular compartments, which results in a complex interplay of downstream signalling pathways. In this Review, we discuss the recent identification of previously unknown pattern recognition receptors and how they complement the repertoire of established receptors.

Mots-clé
Animals, Bacteria/immunology, Bacteria/pathogenicity, Bacterial Infections/immunology, Bacterial Infections/pathology, DEAD-box RNA Helicases/metabolism, Humans, Immunity, Innate, Inflammasomes/immunology, Membrane Proteins/metabolism, Mice, Nuclear Proteins/immunology, Phosphoproteins/immunology, RNA-Binding Proteins/immunology, Receptors, Pattern Recognition/immunology, Signal Transduction, Toll-Like Receptors/immunology
Pubmed
Web of science
Création de la notice
25/10/2017 11:05
Dernière modification de la notice
20/08/2019 14:09
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