Article: article from journal or magazin.
Contribution of dengue fever to the burden of acute febrile illnesses in Papua New Guinea: an age-specific prospective study.
American Journal of Tropical Medicine and Hygiene
Publication types: Journal ArticlePublication Status: ppublish
Malaria is a major contributor to the burden of febrile illnesses in Papua New Guinea (PNG). Dengue fever (DF) is likely to contribute; however, its epidemiology in PNG is poorly understood. We performed a prospective age-stratified study in outpatient clinics investigating the prevalence of DF; 578 patients were enrolled, and 317 patients with a negative rapid diagnostic test (RDT) for malaria were tested for dengue. Malaria was confirmed in 52% (301/578, 95% confidence interval [CI] = 48-56%), DF was diagnosed in 8% (46/578, 95% CI = 6-10%), and 40% (95% CI = 36-44%) had neither diagnosis. Among the 317 malaria RDT-negative patients, 14% (45/317, 95% CI = 10-18%) had DF. The seroprevalence of dengue immunoglobulin G (IgG) was 83% (204/247, 95% CI = 78-87%), and no dengue hemorrhagic fever was seen. This study provides good evidence for the first time that DF is common in PNG and is responsible for 8% of fever episodes. The common occurrence of DF in a population with presumed previous exposure to dengue is an important observation.
Acute Disease, Adolescent, Adult, Child, Child, Preschool, Dengue/epidemiology, Dengue/physiopathology, Female, Fever, Humans, Infant, Infant, Newborn, Malaria/epidemiology, Malaria/physiopathology, Male, Middle Aged, Type="Geographic">Papua New Guinea/epidemiology, Prospective Studies, Seroepidemiologic Studies, Young Adult
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