The central region of human immunodeficiency virus type 1 p6 protein (Gag residues S14-I31) is dispensable for the virus in vitro

Détails

ID Serval
serval:BIB_29E1293D2858
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The central region of human immunodeficiency virus type 1 p6 protein (Gag residues S14-I31) is dispensable for the virus in vitro
Périodique
Journal of General Virology
Auteur(s)
Bleiber  G., Peters  S., Martinez  R., Cmarko  D., Meylan  P., Telenti  A.
ISSN
0022-1317 (Print)
Statut éditorial
Publié
Date de publication
04/2004
Volume
85
Numéro
Pt 4
Pages
921-7
Notes
In Vitro
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Apr
Résumé
The human immunodeficiency virus type 1 p6 region encodes p6(Gag) and the transframe p6(Pol) protein. The Gag frame encodes an N-terminal late assembly L domain and a C-terminal Vpr binding domain. In the Pol frame, substitution at a C-terminal motif decreases protease autocleavage. The role of the highly polymorphic central region of p6, comprising amino acids S14-I31 (p6(Gag)) and R20-D39 (p6(Pol)), is unclear. Analysis of this central region demonstrated that 35 % of p6(Gag) appears to be dispensable for virus propagation in vitro and smaller deletion and insertion polymorphisms can be tolerated in vivo. Extensive Pol deletion (deltaR20-D39, 42 % of p6(Pol)) did not alter protease autocleavage.
Mots-clé
Amino Acid Sequence Gene Products, gag/chemistry/*genetics/*physiology Gene Products, pol/chemistry/genetics/physiology HIV Infections/virology HIV-1/*genetics/isolation & purification/pathogenicity/*physiology Humans Molecular Sequence Data Phenotype Polymorphism, Genetic Recombination, Genetic Sequence Deletion Virulence/genetics/physiology Virus Replication/genetics/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 15:45
Dernière modification de la notice
08/05/2019 16:14
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