Thoracic fat volume is independently associated with coronary vasomotion.

Détails

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Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_29C8F13ED94B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Thoracic fat volume is independently associated with coronary vasomotion.
Périodique
European journal of nuclear medicine and molecular imaging
Auteur(s)
Dunet V., Feihl F., Dabiri A., Allenbach G., Waeber B., Heinzer R., Prior J.O.
ISSN
1619-7089 (Electronic)
ISSN-L
1619-7070
Statut éditorial
Publié
Date de publication
02/2016
Peer-reviewed
Oui
Volume
43
Numéro
2
Pages
280-287
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Thoracic fat has been associated with an increased risk of coronary artery disease (CAD). As endothelium-dependent vasoreactivity is a surrogate of cardiovascular events and is impaired early in atherosclerosis, we aimed at assessing the possible relationship between thoracic fat volume (TFV) and endothelium-dependent coronary vasomotion.
Fifty healthy volunteers without known CAD or major cardiovascular risk factors (CRFs) prospectively underwent a (82)Rb cardiac PET/CT to quantify myocardial blood flow (MBF) at rest, and MBF response to cold pressor testing (CPT-MBF) and adenosine (i.e., stress-MBF). TFV was measured by a 2D volumetric CT method and common laboratory blood tests (glucose and insulin levels, HOMA-IR, cholesterol, triglyceride, hsCRP) were performed. Relationships between CPT-MBF, TFV and other CRFs were assessed using non-parametric Spearman rank correlation testing and multivariate linear regression analysis.
All of the 50 participants (58 ± 10y) had normal stress-MBF (2.7 ± 0.6 mL/min/g; 95 % CI: 2.6-2.9) and myocardial flow reserve (2.8 ± 0.8; 95 % CI: 2.6-3.0) excluding underlying CAD. Univariate analysis revealed a significant inverse relation between absolute CPT-MBF and sex (ρ = -0.47, p = 0.0006), triglyceride (ρ = -0.32, p = 0.024) and insulin levels (ρ = -0.43, p = 0.0024), HOMA-IR (ρ = -0.39, p = 0.007), BMI (ρ = -0.51, p = 0.0002) and TFV (ρ = -0.52, p = 0.0001). MBF response to adenosine was also correlated with TFV (ρ = -0.32, p = 0.026). On multivariate analysis, TFV emerged as the only significant predictor of MBF response to CPT (p = 0.014).
TFV is significantly correlated with endothelium-dependent and -independent coronary vasomotion. High TF burden might negatively influence MBF response to CPT and to adenosine stress, even in persons without CAD, suggesting a link between thoracic fat and future cardiovascular events.

Mots-clé
Adipose Tissue, White/diagnostic imaging, Aged, Coronary Artery Disease/epidemiology, Coronary Circulation, Coronary Vessels/diagnostic imaging, Endothelium, Vascular/diagnostic imaging, Female, Healthy Volunteers, Hemodynamics, Humans, Male, Middle Aged, Multimodal Imaging, Positron-Emission Tomography, Radiopharmaceuticals, Risk Factors, Rubidium Radioisotopes, Thorax/diagnostic imaging, Tomography, X-Ray Computed, Endothelial function, Myocardial blood flow, PET, Thoracic fat
Pubmed
Web of science
Création de la notice
14/01/2016 19:04
Dernière modification de la notice
20/08/2019 14:09
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