Rapid seasonal evolution in innate immunity of wild Drosophila melanogaster.

Détails

ID Serval
serval:BIB_29AC65DC60EB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Rapid seasonal evolution in innate immunity of wild Drosophila melanogaster.
Périodique
Proceedings. Biological sciences
Auteur(s)
Behrman E.L., Howick V.M., Kapun M., Staubach F., Bergland A.O., Petrov D.A., Lazzaro B.P., Schmidt P.S.
ISSN
1471-2954 (Electronic)
ISSN-L
0962-8452
Statut éditorial
Publié
Date de publication
10/01/2018
Peer-reviewed
Oui
Volume
285
Numéro
1870
Pages
20172599
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Résumé
Understanding the rate of evolutionary change and the genetic architecture that facilitates rapid adaptation is a current challenge in evolutionary biology. Comparative studies show that genes with immune function are among the most rapidly evolving genes across a range of taxa. Here, we use immune defence in natural populations of Drosophila melanogaster to understand the rate of evolution in natural populations and the genetics underlying rapid change. We probed the immune system using the natural pathogens Enterococcus faecalis and Providencia rettgeri to measure post-infection survival and bacterial load of wild D. melanogaster populations collected across seasonal time along a latitudinal transect along eastern North America (Massachusetts, Pennsylvania and Virginia). There are pronounced and repeatable changes in the immune response over the approximately 10 generations between spring and autumn collections, with a significant but less distinct difference observed among geographical locations. Genes with known immune function are not enriched among alleles that cycle with seasonal time, but the immune function of a subset of seasonally cycling alleles in immune genes was tested using reconstructed outbred populations. We find that flies containing seasonal alleles in Thioester-containing protein 3 (Tep3) have different functional responses to infection and that epistatic interactions among seasonal Tep3 and Drosomycin-like 6 (Dro6) alleles underlie the immune phenotypes observed in natural populations. This rapid, cyclic response to seasonal environmental pressure broadens our understanding of the complex ecological and genetic interactions determining the evolution of immune defence in natural populations.
Mots-clé
Adaptation, Physiological, Animals, Drosophila Proteins/genetics, Drosophila Proteins/immunology, Drosophila melanogaster/genetics, Drosophila melanogaster/immunology, Drosophila melanogaster/microbiology, Enterococcus faecalis, Evolution, Molecular, Female, Immunity, Innate/genetics, Male, Massachusetts, Pennsylvania, Providencia, Seasons, Virginia, Drosomycin-like 6, Drosophila melanogaster, Thioester-containing protein 3, epistasis, innate immunity, rapid adaptation
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2018 9:11
Dernière modification de la notice
20/08/2019 14:09
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