Endogenous hydrogen sulfide production is essential for dietary restriction benefits.
Details
Serval ID
serval:BIB_297CC988759A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Endogenous hydrogen sulfide production is essential for dietary restriction benefits.
Journal
Cell
ISSN
1097-4172 (Electronic)
ISSN-L
0092-8674
Publication state
Published
Issued date
15/01/2015
Peer-reviewed
Oui
Volume
160
Number
1-2
Pages
132-144
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Dietary restriction (DR) without malnutrition encompasses numerous regimens with overlapping benefits including longevity and stress resistance, but unifying nutritional and molecular mechanisms remain elusive. In a mouse model of DR-mediated stress resistance, we found that sulfur amino acid (SAA) restriction increased expression of the transsulfuration pathway (TSP) enzyme cystathionine γ-lyase (CGL), resulting in increased hydrogen sulfide (H2S) production and protection from hepatic ischemia reperfusion injury. SAA supplementation, mTORC1 activation, or chemical/genetic CGL inhibition reduced H2S production and blocked DR-mediated stress resistance. In vitro, the mitochondrial protein SQR was required for H2S-mediated protection during nutrient/oxygen deprivation. Finally, TSP-dependent H2S production was observed in yeast, worm, fruit fly, and rodent models of DR-mediated longevity. Together, these data are consistent with evolutionary conservation of TSP-mediated H2S as a mediator of DR benefits with broad implications for clinical translation. PAPERFLICK:
Keywords
Animals, Biological Evolution, Caenorhabditis elegans/physiology, Caloric Restriction, Cystathionine gamma-Lyase/metabolism, Cysteine/metabolism, Diet, Drosophila melanogaster/physiology, Female, Hydrogen Sulfide/metabolism, Kidney/blood supply, Kidney/injuries, Life Expectancy, Liver/blood supply, Liver/injuries, Male, Methionine/metabolism, Mice, Knockout, NF-E2-Related Factor 2/genetics, NF-E2-Related Factor 2/metabolism, Reperfusion Injury, Signal Transduction, Stress, Physiological, Transcriptome, Yeasts/physiology
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Careers / P1LAP3_158895
Create date
07/03/2021 12:57
Last modification date
08/03/2021 6:26