Predicting the short-term risk of diabetes in HIV-positive patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study.
Details
Serval ID
serval:BIB_296941E03F01
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Predicting the short-term risk of diabetes in HIV-positive patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study.
Journal
Journal of the International AIDS Society
Working group(s)
D:A:D Study Group
Contributor(s)
Collins S., Shortman N., Butcher D., Rode R., Powderly W., Worm S.W., Sabin C.A., Kamara D., Ellefson M., Smith C., Tverland J., Nielsen J., Mocroft A., Lundgren J.D., Salbøl Brandt R., Rickenbach M., Fanti L., Krum E., Hillebregt M., Geffard S., Sundström A., Delforge M., Fontas E., Torres F., McManus H., Wright S., Kjær J., Sjøl A., de Wolf F., Zaheri S., Hillebregt M., Gras L., Prins J.M., Kuijpers T.W., Scherpbier H.J., Boer K., van der Meer J.T., Wit F.W., Godfried M.H., Reiss P., van der Poll T., Nellen F.J., Lange J.M., Geerlings S.E., van Vugt M., Vrouenraets S.M., Pajkrt D., van der Valk M., Schreij G., Lowe S., Oude Lashof A., Pronk M.J., Bravenboer B., van der Ende M.E., de Vries-Sluijs T.E., Schurink C.A., van der Feltz M., Nouwen J.L., Gelinck L.B., Verbon A., Rijnders B.J., Slobbe L., Hartwig N.G., Driessen G.J., Branger J., Kauffmann R.H., Schippers E.F., Groeneveld P.H., Alleman M.A., Bouwhuis J.W., ten Kate R.W., Soetekouw R., Kroon F.P., van den Broek P.J., van Dissel J.T., Arend S.M., van Nieuwkoop C., de Boer M.G., Jolink H., den Hollander J.G., Pogany K., van Twillert G., Kortmann W., Vriesendorp R., Leyten E.M., ten Napel C.H., Kootstra G.J., Brinkman K., Blok W.L., Frissen P.H., Schouten W.E., van den Berk G.E., Juttmann J.R., van Kasteren M.E., Brouwer A.E., Veenstra J., Lettinga K.D., Mulder J.W., van Gorp E.C., Smit P.M., Weijer S., van Eeden A., Verhagen D.W., Sprenger H.G., Doedens R., Scholvinck E.H., van Assen S., Stek C.J., Koopmans P.P., de Groot R., Keuter M., van der Ven A.J., ter Hofstede H.J., van der Flier M., Brouwer A.M., Dofferhoff A.S., Hoepelman A.I., Mudrikova T., Schneider M.M., Jaspers C.A., Ellerbroek P.M., Peters E.J., Maarschalk-Ellerbroek L.J., Oosterheert J.J., Arends J.E., Wassenberg M.W., van der Hilst J.C., Danner S.A., van Agtmael M.A., de Vocht J., Perenboom R.M., Claessen F.A., Bierman W.F., de Jong E.V., bij de Vaate E.A., Geelen S.P., Wolfs T.F., Richter C., van der Berg J.P., Gisolf E.H., van den Berge M., Stegeman A., van Houte D.P., Polée M.B., van Vonderen M.G., Winkel C., Duits A.J., Salamon R., Beylot J., Dupon M., Le Bras M., Pellegrin J.L., Ragnaud J.M., Dabis F., Chêne G., Jacqmin-Gadda H., Thiébaut R., Lawson-Ayayi S., Lavignolle V., Balestre E., Blaizeau M.J., Decoin M., Formaggio A.M., Delveaux S., Labarerre S., Uwamaliya B., Vimard E., Merchadou L., Palmer G., Touchard D., Dutoit D., Pereira F., Boulant B., Beylot J., Morlat P., Bernard N., Bonarek M., Bonnet F., Coadou B., Gelie P., Jaubert D., Nouts C., Lacoste D., Dupon M., Dutronc H., Cipriano G., Lafarie S., Chossat I., Lacut J.Y., Leng B., Pellegrin J.L., Mercié P., Viallard J.F., Faure I., Rispal P., Cipriano C., Tchamgoué S., Djossou F., Malvy D., Pivetaud J.P., Ragnaud J.M., Chambon D., De La Taille C., Galperine T., Lafarie S., Neau D., Ochoa A., Beylot C., Doutre M.S., Bezian J.H., Moreau J.F., Taupin J.L., Conri C., Constans J., Couzigou P., Castera L., Fleury H., Lafon M.E., Masquelier B., Pellegrin I., Trimoulet P., Moreau F., Mestre C., Series C., Taytard A., Law M., Petoumenos K., McManus H., Wright S., Bendall C., Moore R., Edwards S., Hoy J., Watson K., Roth N., Nicholson J., Bloch M., Franic T., Baker D., Vale R., Carr A., Cooper D., Chuah J., Ngieng M., Nolan D., Skett J., Calvo G., Torres F., Mateu S., Domingo P., Sambeat M.A., Gatell J., Del Cacho E., Cadafalch J., Fuster M., Codina C., Sirera G., Vaqué A., Clumeck N., De Wit S., Gerard M., Kabeya K., Konopnicki D., Libois A., Payen M.C., Van Laethem Y., Neaton J., Bartsch G., El-Sadr W.M., Krum E., Thompson G., Wentworth D., Luskin-Hawk R., Telzak E., Abrams D.I., Cohn D., Markowitz N., Arduino R., Mushatt D., Friedland G., Perez G., Tedaldi E., Fisher E., Gordin F., Crane L.R., Sampson J., Baxter J., Kirk O., Mocroft A., Ellefson M., Phillips A.N., Lundgren J.D., Losso M., Elias C., Vetter N., Zangerle R., Karpov I., Vassilenko A., Mitsura V.M., Suetnov O., Clumeck N., De Wit S., Poll B., Colebunders R., Vandekerckhove L., Hadziosmanovic V., Kostov K., Begovac J., Machala L., Rozsypal H., Sedlacek D., Nielsen J., Kronborg G., Benfield T., Larsen M., Gerstoft J., Katzenstein T., Hansen A.B., Skinhøj P., Pedersen C., Oestergaard L., Zilmer K., Smidt J., Ristola M., Katlama C., Viard J.P., Girard P.M., Livrozet J.M., Vanhems P., Pradier C., Dabis F., Neau D., Rockstroh J., Schmidt R., van Lunzen J., Degen O., Stellbrink H.J., Staszewski S., Bogner J., Fätkenheuer G., Kosmidis J., Gargalianos P., Xylomenos G., Perdios J., Panos G., Filandras A., Karabatsaki E., Sambatakou H., Banhegyi D., Mulcahy F., Yust I., Turner D., Burke M., Pollack S., Hassoun G., Maayan S., Chiesi A., Esposito R., Mazeu I., Mussini C., Arici C., Pristera R., Mazzotta F., Gabbuti A., Vullo V., Lichtner M., Chirianni A., Montesarchio E., Gargiulo M., Antonucci G., Testa A., Narciso P., Vlassi C., Zaccarelli M., Lazzarin A., Finazzi R., Galli M., Ridolfo A., d'Arminio Monforte A., Rozentale B., Aldins P., Chaplinskas S., Hemmer R., Staub T., Reiss P., Bruun J., Maeland A., Ormaasen V., Knysz B., Gasiorowski J., Horban A., Bakowska E., Prokopowicz D., Flisiak R., Boron-Kaczmarska A., Pynka M., Beniowski M., Mularska E., Trocha H., Jablonowska E., Malolepsza E., Wojcik K., Antunes F., Valadas E., Mansinho K., Maltez F., Duiculescu D., Rakhmanova A., Vinogradova E., Buzunova S., Jevtovic D., Mokráš M., Staneková D., Tomazic J., González-Lahoz J., Soriano V., Martin-Carbonero L., Labarga P., Moreno S., Clotet B., Jou A., Paredes R., Tural C., Puig J., Bravo I., Gatell J.M., Miró J.M., Domingo P., Gutierrez M., Mateo G., Sambeat M.A., Karlsson A., Persson P.O., Flamholc L., Ledergerber B., Weber R., Francioli P., Cavassini M., Hirschel B., Boffi E., Furrer H., Battegay M., Elzi L., Kravchenko E., Chentsova N., Kutsyna G., Servitskiy S., Antoniak S., Krasnov M., Barton S., Johnson A.M., Mercey D., Phillips A., Johnson M.A., Mocroft A., Murphy M., Weber J., Scullard G., Fisher M., Leen C., Morfeldt L., Thulin G., Sundström A., Åkerlund B., Koppel K., Karlsson A., Flamholc L., Håkangård C., Moroni M., Antinori A., Carosi G., Cauda R., Chiodo F., Di Perri G., Galli M., Ghinelli F., Iardino R., Ippolito G., Lazzarin A., Mazzotta F., Panebianco R., Pastore G., Perno C.F., Ammassari A., Antinori A., Balotta C., Bonfanti P., Capobianchi M.R., Castagna A., Ceccherini-Silberstein F., Cozzi-Lepri A., De Luca A., Gervasoni C., Girardi E., Lo Caputo S., Maggiolo F., Murri R., Mussini C., Puoti M., Torti C., Cozzi-Lepri A., Fanti I., Formenti T., Montroni M., Giacometti A., Costantini A., Riva A., Tirelli U., Martellotta F., Pastore G., Ladisa N., Suter F., Maggiolo F., Chiodo F., Verucchi G., Fiorini C., Carosi G., Cristini G., Torti C., Minardi C., Bertelli D., Quirino T., Abeli C., Manconi P.E., Piano P., Vecchiet J., Farenga M., Carnevale G., Lorenzotti S., Ghinelli F., Sighinolfi L., Leoncini F., Mazzotta F., Pozzi M., Pagano G., Cassola G., Viscoli G., Alessandrini A., Piscopo R., Mazzarello G., Soscia F., Tacconi L., Orani A., Rossotto R., Tommasi D., Congedo P., Chiodera A., Castelli P., Galli M., Lazzarin A., Rizzardini G., Schlacht I., Ridolfo A.L., Foschi A., Castagna A., Salpietro S., Merli S., Melzi S., Moioli M.C., Cicconi P., Formenti T., Esposito R., Mussini C., Gori A., Abrescia N., Chirianni A., Izzo C.M., De Marco M., Viglietti R., Manzillo E., Ferrari C., Pizzaferri P., Baldelli F., Camanni G., Magnani G., Ursitti M.A., Arlotti M., Ortolani P., Cauda R., Andreoni M., Antinori A., Antonucci G., Narciso P., Tozzi V., Vullo V., Zaccarelli M., Acinapura R., De Longis P., Trotta M.P., Lichtner M., Carletti F., Mura M.S., Madeddu G., Caramello P., Di Perri G., Orofino G.C., Raise E., Ebo F., Pellizzer G., Buonfrate D., Pradier C., Fontas E., Caissotti C., Dellamonica P., Bentz L., Bernard E., Cua E., De Salvador-Guillouet F., Durant J., Farhad R., Ferrando S., Mondain-Miton V., Perbost I., Prouvost-Keller B., Pugliese P., Rahelinirina V., Roger P.M., Vassallo M., Dollet K., Barth J., Bernasconi E., Böni J., Bucher H.C., Burton-Jeangros C., Calmy A., Cavassini M., Cellerai C., Dubs R., Egger M., Elzi L., Fehr J., Flepp M., Francioli P., Furrer H., Fux C.A., Gorgievski M., Günthard H., Hasse B., Hirsch H.H., Hirschel B., Hösli I., Kahlert C., Kaiser L., Keiser O., Kind C., Klimkait T., Kovari H., Ledergerber B., Martinetti G., Martinez de Tejada B., Müller N., Nadal D., Pantaleo G., Rauch A., Regenass S., Rickenbach M., Rudin C., Schmid P., Schultze D., Schöni-Affolter F., Schüpbach J., Speck R., Taffé P., Telenti A., Trkola A., Vernazza P., von Wyl V., Weber R., Yerly S.
ISSN
1758-2652 (Electronic)
ISSN-L
1758-2652
Publication state
Published
Issued date
10/10/2012
Peer-reviewed
Oui
Volume
15
Number
2
Pages
17426
Language
english
Notes
Publication types: Evaluation Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Abstract
HIV-positive patients receiving combination antiretroviral therapy (cART) frequently experience metabolic complications such as dyslipidemia and insulin resistance, as well as lipodystrophy, increasing the risk of cardiovascular disease (CVD) and diabetes mellitus (DM). Rates of DM and other glucose-associated disorders among HIV-positive patients have been reported to range between 2 and 14%, and in an ageing HIV-positive population, the prevalence of DM is expected to continue to increase. This study aims to develop a model to predict the short-term (six-month) risk of DM in HIV-positive populations and to compare the existing models developed in the general population.
All patients recruited to the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) study with follow-up data, without prior DM, myocardial infarction or other CVD events and with a complete DM risk factor profile were included. Conventional risk factors identified in the general population as well as key HIV-related factors were assessed using Poisson-regression methods. Expected probabilities of DM events were also determined based on the Framingham Offspring Study DM equation. The D:A:D and Framingham equations were then assessed using an internal-external validation process; area under the receiver operating characteristic (AUROC) curve and predicted DM events were determined.
Of 33,308 patients, 16,632 (50%) patients were included, with 376 cases of new onset DM during 89,469 person-years (PY). Factors predictive of DM included higher glucose, body mass index (BMI) and triglyceride levels, and older age. Among HIV-related factors, recent CD4 counts of <200 cells/µL and lipodystrophy were predictive of new onset DM. The mean performance of the D:A:D and Framingham equations yielded AUROC of 0.894 (95% CI: 0.849, 0.940) and 0.877 (95% CI: 0.823, 0.932), respectively. The Framingham equation over-predicted DM events compared to D:A:D for lower glucose and lower triglycerides, and for BMI levels below 25 kg/m(2).
The D:A:D equation performed well in predicting the short-term onset of DM in the validation dataset and for specific subgroups provided better estimates of DM risk than the Framingham.
All patients recruited to the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) study with follow-up data, without prior DM, myocardial infarction or other CVD events and with a complete DM risk factor profile were included. Conventional risk factors identified in the general population as well as key HIV-related factors were assessed using Poisson-regression methods. Expected probabilities of DM events were also determined based on the Framingham Offspring Study DM equation. The D:A:D and Framingham equations were then assessed using an internal-external validation process; area under the receiver operating characteristic (AUROC) curve and predicted DM events were determined.
Of 33,308 patients, 16,632 (50%) patients were included, with 376 cases of new onset DM during 89,469 person-years (PY). Factors predictive of DM included higher glucose, body mass index (BMI) and triglyceride levels, and older age. Among HIV-related factors, recent CD4 counts of <200 cells/µL and lipodystrophy were predictive of new onset DM. The mean performance of the D:A:D and Framingham equations yielded AUROC of 0.894 (95% CI: 0.849, 0.940) and 0.877 (95% CI: 0.823, 0.932), respectively. The Framingham equation over-predicted DM events compared to D:A:D for lower glucose and lower triglycerides, and for BMI levels below 25 kg/m(2).
The D:A:D equation performed well in predicting the short-term onset of DM in the validation dataset and for specific subgroups provided better estimates of DM risk than the Framingham.
Keywords
Adult, Anti-HIV Agents/administration & dosage, Anti-HIV Agents/adverse effects, Antiretroviral Therapy, Highly Active/adverse effects, Antiretroviral Therapy, Highly Active/methods, Decision Support Techniques, Diabetes Mellitus/chemically induced, Drug-Related Side Effects and Adverse Reactions/epidemiology, Female, HIV Infections/complications, HIV Infections/drug therapy, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Risk Assessment
Pubmed
Web of science
Open Access
Yes
Create date
30/01/2023 19:30
Last modification date
31/01/2023 6:55
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