Article: article from journal or magazin.
Molecular mechanisms that regulate auditory hair-cell differentiation in the mammalian cochlea.
Publication types: Journal Article
Mechanosensory hair cells of the vertebrate cochlea offer an excellent developmental system to study cell-fate specification, and to gain insight into the many human neurological deficits which result in a hearing loss, by affecting primarily the hair cells. Therefore, there is great interest in studying the molecular mechanisms that regulate their specification and differentiation. Recent studies, based mostly on loss-of-function experiments that target the role of Notch signaling and basic helix-loop-helix genes in inner-ear development have indicated that they can regulate mechanosensory hair cell-fate specification and their initial differentiation.
Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation/physiology, Cell Lineage/physiology, DNA-Binding Proteins/metabolism, Gene Expression Regulation, Developmental/physiology, Hair Cells, Auditory/embryology, Hair Cells, Auditory/metabolism, Humans, Membrane Proteins/metabolism, Protein Structure, Tertiary/physiology, Receptor, Notch1, Receptors, Cell Surface, Stem Cells/metabolism, Stem Cells/ultrastructure, Transcription Factors/metabolism
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