Treating pulmonary hypertension in pediatrics.

Details

Serval ID
serval:BIB_290515123049
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Treating pulmonary hypertension in pediatrics.
Journal
Expert Opinion On Pharmacotherapy
Author(s)
Lador F., Sekarski N., Beghetti M.
ISSN
1744-7666 (Electronic)
ISSN-L
1465-6566
Publication state
Published
Issued date
2015
Volume
16
Number
5
Pages
711-726
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish Document Type: Review
Abstract
INTRODUCTION: Pulmonary hypertension is a hemodynamic condition occurring rarely in pediatrics. Nevertheless, it is associated with significant morbidity and mortality. When characterized by progressive pulmonary vascular structural changes, the disease is called pulmonary arterial hypertension (PAH). It results in increased pulmonary vascular resistance and eventual right ventricular failure. In the vast majority of cases, pediatric PAH is idiopathic or associated with congenital heart disease, and, contrary to adult PAH, is rarely associated with connective tissue, portal hypertension, HIV infection or thromboembolic disease.
AREAS COVERED: This article reviews the current drug therapies available for the management of pediatric PAH. These treatments target the recognized pathophysiological pathways of PAH with endothelin-1 receptor antagonists, prostacyclin analogs and PDE type 5 inhibitors. New treatments and explored pathways are briefly discussed.
EXPERT OPINION: Although there is still no cure for PAH, quality of life and survival have been improved significantly with specific drug therapies. Nevertheless, management of pediatric PAH remains challenging, and depends mainly on results from adult clinical trials and pediatric experts. Further research on PAH-specific treatments in the pediatric population and data from international registries are needed to identify optimal therapeutic strategies and treatment goals in the pediatric population.
Pubmed
Web of science
Create date
10/04/2015 18:11
Last modification date
20/08/2019 13:08
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