Will Widespread Synthetic Opioid Consumption Induce Epigenetic Consequences in Future Generations?

Détails

Ressource 1Télécharger: PMID30018553.pdf (780.87 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_28E5D540F1EB
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Will Widespread Synthetic Opioid Consumption Induce Epigenetic Consequences in Future Generations?
Périodique
Frontiers in pharmacology
Auteur(s)
Gilardi F., Augsburger M., Thomas A.
ISSN
1663-9812 (Print)
ISSN-L
1663-9812
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
9
Pages
702
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
PDF: mini review
Résumé
A growing number of evidence demonstrates that ancestral exposure to xenobiotics (pollutants, drugs of abuse, etc.) can perturb the physiology and behavior of descendants. Both maternal and paternal transmission of phenotype across generations has been proved, demonstrating that parental drug history may have significant implications for subsequent generations. In the last years, the burden of novel synthetic opioid (NSO) consumption, due to increased medical prescription of pain medications and to easier accessibility of these substances on illegal market, is raising new questions first in term of public health, but also about the consequences of the parental use of these drugs on future generations. Besides being associated to the neonatal abstinence syndrome, <i>in utero</i> exposure to opioids has an impact on neuronal development with long-term repercussions that are potentially transmitted to subsequent generations. In addition, recent reports suggest that opioid use even before conception influences the reactivity to opioids of the progeny and the following generations, likely through epigenetic mechanisms. This review describes the current knowledge about the transgenerational effects of opioid consumption. We summarize the preclinical and clinical findings showing the implications for the subsequent generations of parental exposure to opioids earlier in life. Limitations of the existing data on NSOs and new perspectives of the research are also discussed, as well as clinical and forensic consequences.
Mots-clé
epigenetics, opioids, parental exposure, prenatal exposure, transgenerational inheritance, vulnerability
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/07/2018 12:08
Dernière modification de la notice
20/08/2019 14:08
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