Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity.

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Serval ID
serval:BIB_28DC39B0ABC7
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity.
Journal
Frontiers in Computational Neuroscience
Author(s)
De Pittà M., Volman V., Berry H., Parpura V., Volterra A., Ben-Jacob E.
ISSN
1662-5188 (Electronic)
ISSN-L
1662-5188
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
6
Pages
98
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish
Abstract
The complexity of the signaling network that underlies astrocyte-synapse interactions may seem discouraging when tackled from a theoretical perspective. Computational modeling is challenged by the fact that many details remain hitherto unknown and conventional approaches to describe synaptic function are unsuitable to explain experimental observations when astrocytic signaling is taken into account. Supported by experimental evidence is the possibility that astrocytes perform genuine information processing by means of their calcium signaling and are players in the physiological setting of the basal tone of synaptic transmission. Here we consider the plausibility of this scenario from a theoretical perspective, focusing on the modulation of synaptic release probability by the astrocyte and its implications on synaptic plasticity. The analysis of the signaling pathways underlying such modulation refines our notion of tripartite synapse and has profound implications on our understanding of brain function.
Pubmed
Web of science
Open Access
Yes
Create date
21/01/2013 10:19
Last modification date
20/08/2019 13:08
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