Euteleost fish genomes are characterized by expansion of gene families.

Details

Serval ID
serval:BIB_28AB4513BA82
Type
Article: article from journal or magazin.
Collection
Publications
Title
Euteleost fish genomes are characterized by expansion of gene families.
Journal
Genome Research
Author(s)
Robinson-Rechavi M., Marchand O., Escriva H., Bardet P.L., Zelus D., Hughes S., Laudet V.
ISSN
1088-9051 (Print)
ISSN-L
1088-9051
Publication state
Published
Issued date
2001
Volume
11
Number
5
Pages
781-788
Language
english
Abstract
The presence of additional hox clusters in the zebrafish has led to the hypothesis that there was a whole genome duplication at the origin of modern fish. To investigate the generality of this assumption, we analyzed all available actinopterygian fish gene families, and sequenced nuclear receptors from diverse teleost fish. The origin and timing of duplications was systematically determined by phylogenetic analysis. More genes are indeed found in zebrafish than in mouse. This abundance is shared by all major groups of euteleost fish, but not by eels. Phylogenetic analysis shows that it may result from frequent independent duplications, rather than from an ancestral genome duplication. We predict two zebrafish paralogs for most mouse or human genes, thus expressing a note of caution in functional comparison of fish and mammalian genomes. Redundancy appears to be the rule in fish developmental genetics. Finally, our results imply that the outcome of genome projects cannot be extrapolated easily between fish species.
Keywords
Animals, Eels/genetics, Fishes/genetics, Flatfishes/genetics, Gene Duplication, Genes, Duplicate/genetics, Genome, Humans, Mice, Molecular Sequence Data, Multigene Family/genetics, Perciformes/genetics, Phylogeny, Receptors, Cytoplasmic and Nuclear/genetics, Salmoniformes/genetics, Species Specificity, Zebrafish/genetics
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 17:47
Last modification date
20/08/2019 13:08
Usage data