Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase.

Détails

Ressource 1Télécharger: ijms-20-00812-v2.pdf (3277.82 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_288D9DD0B3BE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase.
Périodique
International journal of molecular sciences
Auteur(s)
Oh HYP, Ellero-Simatos S., Manickam R., Tan N.S., Guillou H., Wahli W.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Statut éditorial
Publié
Date de publication
14/02/2019
Peer-reviewed
Oui
Volume
20
Numéro
4
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Living organisms display internal biological rhythms, which are an evolutionarily conserved adaptation to the environment that drives their rhythmic behavioral and physiological activities. The gut microbiota has been proposed, in association with diet, to regulate the intestinal peripheral clock. However, the effect of gut dysbiosis on liver remains elusive, despite that germfree mice show alterations in liver metabolic functions and the hepatic daily rhythm. We analyzed whether the disruption of gut microbial populations with various antibiotics would differentially impact liver functions in mice. Our results support the notion of an impact on the hepatic biological rhythm by gram-positive bacteria. In addition, we provide evidence for differential roles of gut microbiota spectra in xenobiotic metabolism that could protect against the harmful pharmacological effects of drugs. Our results underscore a possible link between liver cell proliferation and gram-positive bacteria.
Mots-clé
Animals, Cell Proliferation/drug effects, Circadian Clocks/genetics, Dysbiosis/drug therapy, Dysbiosis/genetics, Dysbiosis/physiopathology, Gastrointestinal Microbiome/genetics, Gastrointestinal Microbiome/physiology, Gram-Positive Bacteria/genetics, Gram-Positive Bacteria/physiology, Humans, Intestines/microbiology, Intestines/physiology, Liver/drug effects, Liver/microbiology, Liver/physiology, Mice, antibiotics, circadian rhythm, gene expression, gut microbiota, liver
Pubmed
Web of science
Open Access
Oui
Création de la notice
31/03/2019 15:23
Dernière modification de la notice
20/08/2019 14:08
Données d'usage