Notch1 control of oligodendrocyte differentiation in the spinal cord.
Details
State: Public
Version: author
Serval ID
serval:BIB_27E702FE5FB7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Notch1 control of oligodendrocyte differentiation in the spinal cord.
Journal
The Journal of cell biology
ISSN
0021-9525
Publication state
Published
Issued date
2002
Peer-reviewed
Oui
Volume
158
Number
4
Pages
709-18
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
We have selectively inhibited Notch1 signaling in oligodendrocyte precursors (OPCs) using the Cre/loxP system in transgenic mice to investigate the role of Notch1 in oligodendrocyte (OL) development and differentiation. Early development of OPCs appeared normal in the spinal cord. However, at embryonic day 17.5, premature OL differentiation was observed and ectopic immature OLs were present in the gray matter. At birth, OL apoptosis was strongly increased in Notch1 mutant animals. Premature OL differentiation was also observed in the cerebrum, indicating that Notch1 is required for the correct spatial and temporal regulation of OL differentiation in various regions of the central nervous system. These findings establish a widespread function of Notch1 in the late steps of mammalian OPC development in vivo.
Keywords
Animals, Apoptosis, Cell Differentiation, Membrane Proteins, Mice, Mice, Transgenic, Mutation, Oligodendroglia, Prosencephalon, Receptor, Notch1, Receptors, Cell Surface, Spinal Cord, Transcription Factors
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:39
Last modification date
20/08/2019 13:07
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