Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.

Details

Serval ID
serval:BIB_27B684BDC6AE
Type
Article: article from journal or magazin.
Collection
Publications
Title
Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.
Journal
Science
Author(s)
Cases O., Seif I., Grimsby J., Gaspar P., Chen K., Pournin S., Müller U., Aguet M., Babinet C., Shih J.C., Demaeyer E.
ISSN
0036-8075 (Print)
ISSN-L
0036-8075
Publication state
Published
Issued date
1995
Volume
268
Number
5218
Pages
1763-1766
Language
english
Abstract
Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. A line of transgenic mice was isolated in which transgene integration caused a deletion in the gene encoding MAOA, providing an animal model of MAOA deficiency. In pup brains, serotonin concentrations were increased up to ninefold, and serotonin-like immunoreactivity was present in catecholaminergic neurons. In pup and adult brains, norepinephrine concentrations were increased up to twofold, and cytoarchitectural changes were observed in the somatosensory cortex. Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine. Adults manifested a distinct behavioral syndrome, including enhanced aggression in males.
Keywords
Aggression/physiology, Amino Acid Sequence, Animals, Base Sequence, Blotting, Southern, Brain/metabolism, Disease Models, Animal, Dopamine/metabolism, Female, Interferon-beta/genetics, Male, Mice, Mice, Inbred C3H, Mice, Transgenic, Molecular Sequence Data, Monoamine Oxidase/deficiency, Norepinephrine/metabolism, Sequence Deletion, Serotonin/metabolism
Pubmed
Web of science
Create date
28/01/2008 11:37
Last modification date
20/08/2019 13:06
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