DNA polymorphism of the class II genes in DR4 cells
Details
Serval ID
serval:BIB_27B082EBB201
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
DNA polymorphism of the class II genes in DR4 cells
Journal
Disease Markers
ISSN
0278-0240 (Print)
Publication state
Published
Issued date
06/1986
Volume
4
Number
1-2
Pages
165-72
Notes
Journal Article --- Old month value: Jun
Abstract
The restriction fragment length polymorphisms of the DR-beta, DQ-alpha and -beta genes in 11 DR4 homozygous cells of different Dw type were investigated. The results showed that, with the enzyme-probe combination studied, the DR beta restriction polymorphism patterns were constant between the different cell lines. With the DQ alpha and DQ beta probes, variations in restriction patterns were obtained. No absolute correlation was seen between RFLP and Dw types. These differences may be useful in the investigation of the association between RA and specific subsets of DR4.
Keywords
Cell Line
DNA/*analysis
*Genes, MHC Class II
Genetic Markers
HLA-D Antigens/*genetics
HLA-DQ Antigens/genetics
HLA-DR Antigens/*genetics
HLA-DR4 Antigen
Humans
*Polymorphism, Genetic
*Polymorphism, Restriction Fragment Length
Pubmed
Web of science
Create date
25/01/2008 9:39
Last modification date
20/08/2019 14:06