A Novel Earwax Method to Measure Acute and Chronic Glucose Levels.

Details

Ressource 1Download: 33321856_BIB_279E053EFFE4.pdf (1536.05 [Ko])
State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_279E053EFFE4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A Novel Earwax Method to Measure Acute and Chronic Glucose Levels.
Journal
Diagnostics
Author(s)
Herane-Vives A., Espinoza S., Sandoval R., Ortega L., Alameda L., Young A.H., Arnone D., Hayes A., Benöhr J.
ISSN
2075-4418 (Print)
ISSN-L
2075-4418
Publication state
Published
Issued date
10/12/2020
Peer-reviewed
Oui
Volume
10
Number
12
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Diabetes is the fourth cause of death globally. To date, there is not a practical, as well as an accurate sample for reflecting chronic glucose levels. We measured earwax glucose in 37 controls. Participants provided standard serum, glycated hemoglobin (HbA <sub>1c</sub> ) and earwax samples at two time-points, one month apart. The specimens measured baseline fasting glucose, a follow-up postprandial glucose level and a between sample chronic glucose, calculated using the average level on the two occasions. The baseline earwax sample was obtained using a clinical method and the follow-up using a novel self-sampling earwax device. The earwax analytic time was significantly faster using the novel device, in comparison to the clinical use of the syringe. Earwax accurately reflected glucose at both assessments with stronger correlations than HbA <sub>1c</sub> . Follow-up postprandial concentrations were more significant than their respective fasting baseline concentrations, reflecting differences in fasting and postprandial glycemia and more efficient standardization at follow up. Earwax demonstrated to be more predictable than HbA <sub>1c</sub> in reflecting systemic fasting, postprandial and long-term glucose levels, and to be less influenced by confounders. Earwax glucose measurements were approximately 60% more predictable than HbA <sub>1c</sub> in reflecting glycemia over a month. The self-sampling device provided a sample that might accurately reflect chronic glycemia.
Keywords
diabetes, diagnosis, earwax, glucose, glycated hemoglobin
Pubmed
Web of science
Open Access
Yes
Create date
05/08/2022 15:28
Last modification date
16/04/2024 6:11
Usage data