Neuronal traits are required for glucose-induced insulin secretion.

Détails

ID Serval
serval:BIB_26FD99AF4BAC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Neuronal traits are required for glucose-induced insulin secretion.
Périodique
FEBS letters
Auteur(s)
Abderrahmani A., Niederhauser G., Plaisance V., Haefliger J.A., Regazzi R., Waeber G.
ISSN
0014-5793
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
565
Numéro
1-3
Pages
133-8
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
The transcriptional repressor RE1 silencer transcription factor (REST) is an important factor that restricts some neuronal traits to neurons. Since these traits are also present in pancreatic beta-cells, we evaluated their role by generating a model of insulin-secreting cells that express REST. The presence of REST led to a decrease in expression of its known target genes, whereas insulin expression and its cellular content were conserved. As a consequence of REST expression, the capacity to secrete insulin in response to mitochondrial fuels, a particularity of mature beta-cells, was impaired. These data provide evidence that REST target genes are required for an appropriate glucose-induced insulin secretion.
Mots-clé
Animals, Blotting, Northern, Cell Line, Coloring Agents, DNA, Complementary, DNA-Binding Proteins, Glucose, Insulin, Islets of Langerhans, Mice, Nerve Tissue Proteins, Neurons, Potassium Chloride, Promoter Regions, Genetic, RNA, RNA, Messenger, Repressor Proteins, Tetrazolium Salts, Thiazoles, Time Factors, Transcription, Genetic, Transfection
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 15:30
Dernière modification de la notice
20/08/2019 14:05
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