Chronic Neovascular Central Serous Chorioretinopathy: A Stress/Rest Optical Coherence Tomography Angiography Study.

Details

Serval ID
serval:BIB_26E221CAF301
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Title
Chronic Neovascular Central Serous Chorioretinopathy: A Stress/Rest Optical Coherence Tomography Angiography Study.
Journal
American journal of ophthalmology
Author(s)
Lupidi M., Fruttini D., Eandi C.M., Nicolò M., Cabral D., Tito S., Cagini C., Cardillo Piccolino F.
ISSN
1879-1891 (Electronic)
ISSN-L
0002-9394
Publication state
Published
Issued date
03/2020
Peer-reviewed
Oui
Volume
211
Pages
63-75
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
To compare optical coherence tomography-angiography (OCT-A) performed during physical exercise (stress OCT-A) to the basal examination (rest OCT-A) in the imaging of choroidal neovascularization (CNV) in patients with chronic central serous chorioretinopathy (CSCR).
Prospective, cohort study.
This multicenter study included 29 consecutive patients with chronic CSCR and flat irregular pigment epithelium detachments (FIPEDs). All patients underwent rest and stress OCT-A (i.e., hand-grip test [HGT]). Systemic hemodynamic data were recorded during the examinations. Rest and stress OCT-A in the en-face and cross-sectional views were qualitatively compared to establish the degree of evidence of flow signals due to CNVs. The en-face angiograms underwent additional automated quantitative analysis to assess the rate of change in neovascular parameters during the stress condition.
Blood pressure significantly increased during the HGT (P = 0.001). Considering both the en-face and the cross-sectional images, CNV was identified in 13 eyes with the rest OCT-A and in 22 eyes with the stress OCT-A (P = 0.001). Cross-sectional imaging was more sensitive than en-face imaging in detecting neovascular blood flow signals under both rest (P = 0.125) and stress (P = 0.001) conditions. The quantitative analysis showed a significantly greater neovascular area and fractal dimension on the stress OCT-A (P = 0.002).
Performing OCT-A during HGT enhances the sensitivity of the examination in detecting CNV in chronic CSCR. The increased neovascular perfusion following the induced increase of blood pressure is consistent with choroidal blood flow dysregulation in patients with CSCR and indicates new areas of discussion about CNV in this disease.
Keywords
Adult, Blood Pressure/physiology, Central Serous Chorioretinopathy/diagnosis, Central Serous Chorioretinopathy/physiopathology, Choroid/blood supply, Choroidal Neovascularization/diagnosis, Choroidal Neovascularization/physiopathology, Chronic Disease, Exercise, Exercise Test, Female, Fluorescein Angiography, Humans, Intraocular Pressure/physiology, Male, Middle Aged, Prospective Studies, Regional Blood Flow/physiology, Retinal Vessels/physiology, Sensitivity and Specificity, Tomography, Optical Coherence, Visual Acuity/physiology
Pubmed
Web of science
Open Access
Yes
Create date
12/03/2021 19:41
Last modification date
26/03/2021 6:35
Usage data