Immunodéficience commune variable: ce qu'il faut savoir [Common variable immune deficiency: what you need to know].

Details

Serval ID
serval:BIB_267159E0AF97
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunodéficience commune variable: ce qu'il faut savoir [Common variable immune deficiency: what you need to know].
Journal
Revue Médicale Suisse
Author(s)
Buss G., Comte D., Spertini F., Bart P.A., Petitpierre S.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
2012
Volume
8
Number
337
Pages
859-864
Language
french
Notes
Publication types: English Abstract ; Journal Article
Abstract
Common variable immune deficiency is the most frequent primary immune deficiency, characterized mainly by a disorder of B lymphocytes differentiation and a deficit in immunoglobulins. The clinical manifestations include recurrent infections, non-infectious lung and digestive involvements, autoimmune diseases, and an increased susceptibility to cancers. Recent breakthroughs have been made in the understanding of some genetic mechanisms of the disease. Replacement therapy with intravenous immunoglobulins remains the treatment of choice, which allows significant improvement in the survival and quality of life. However progress should be made in the understanding of the pathophysiology and in the early detection of this disease, since a delay in the diagnosis may have harmful consequences in terms of morbidity and mortality.
Keywords
Common Variable Immunodeficiency/diagnosis, Common Variable Immunodeficiency/drug therapy, Disease Susceptibility, Humans, Immunoglobulin Isotypes/blood, Immunoglobulins, Intravenous/therapeutic use
Pubmed
Create date
11/07/2012 10:39
Last modification date
20/08/2019 13:05
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