Evoked axonal oxytocin release in the central amygdala attenuates fear response.

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_260A349557CD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evoked axonal oxytocin release in the central amygdala attenuates fear response.
Périodique
Neuron
Auteur(s)
Knobloch H.S., Charlet A., Hoffmann L.C., Eliava M., Khrulev S., Cetin A.H., Osten P., Schwarz M.K., Seeburg P.H., Stoop R., Grinevich V.
ISSN
1097-4199 (Electronic)
ISSN-L
0896-6273
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
73
Numéro
3
Pages
553-566
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
The hypothalamic neuropeptide oxytocin (OT), which controls childbirth and lactation, receives increasing attention for its effects on social behaviors, but how it reaches central brain regions is still unclear. Here we gained by recombinant viruses selective genetic access to hypothalamic OT neurons to study their connectivity and control their activity by optogenetic means. We found axons of hypothalamic OT neurons in the majority of forebrain regions, including the central amygdala (CeA), a structure critically involved in OT-mediated fear suppression. In vitro, exposure to blue light of channelrhodopsin-2-expressing OT axons activated a local GABAergic circuit that inhibited neurons in the output region of the CeA. Remarkably, in vivo, local blue-light-induced endogenous OT release robustly decreased freezing responses in fear-conditioned rats. Our results thus show widespread central projections of hypothalamic OT neurons and demonstrate that OT release from local axonal endings can specifically control region-associated behaviors.
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/03/2012 19:22
Dernière modification de la notice
20/08/2019 13:04
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