Article: article from journal or magazin.
Improvement of chronic congestive heart-failure by oral captopril
Catopril, an inhibitor of angiotensin converting enzyme, was given orally during cardiac catheterisation to 6 normotensive patients with refractory congestive heart-failure. 60--180 minutes after administration of 25 mg captopril, arterial pressure fell by 25%, cardiac index rose by 38%, and left-ventricular pressure and right-atrial pressure fell by 25% and 40% respectively. Plasma-renin activity rose while plasma noradrenaline and aldosterone fell. These data suggest that, in the short term, captopril can reduce both preload and afterload, and improve cardiac function, in refractory congestive heart-failure.
Administration, OralAdultAldosterone Antagonists*Angiotensin-Converting Enzyme InhibitorsBlood Pressure/drug effectsCardiac Output/drug effectsChronic DiseaseDrug EvaluationHeart Failure/*drug therapy/physiopathologyHumansMaleMiddle AgedNorepinephrine/antagonists & inhibitorsProline/administration & dosage/*analogs & derivativesRenin/bloodVascular Resistance/drug effects
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