Quetiapine v. lithium in the maintenance phase following a first episode of mania: randomised controlled trial.

Détails

ID Serval
serval:BIB_25A837C6004F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Quetiapine v. lithium in the maintenance phase following a first episode of mania: randomised controlled trial.
Périodique
The British journal of psychiatry
Auteur(s)
Berk M., Daglas R., Dandash O., Yücel M., Henry L., Hallam K., Macneil C., Hasty M., Pantelis C., Murphy B.P., Kader L., Damodaran S., Wong MTH, Conus P., Ratheesh A., McGorry P.D., Cotton S.M.
ISSN
1472-1465 (Electronic)
ISSN-L
0007-1250
Statut éditorial
Publié
Date de publication
06/2017
Peer-reviewed
Oui
Volume
210
Numéro
6
Pages
413-421
Langue
anglais
Notes
Publication types: Journal Article ; Randomized Controlled Trial
Publication Status: ppublish
Résumé
javax.xml.bind.JAXBElement@5d55dac4
Lithium and quetiapine are considered standard maintenance agents for bipolar disorder yet it is unclear how their efficacy compares with each other. javax.xml.bind.JAXBElement@17dab71d To investigate the differential effect of lithium and quetiapine on symptoms of depression, mania, general functioning, global illness severity and quality of life in patients with recently stabilised first-episode mania. javax.xml.bind.JAXBElement@7f326b9f Maintenance trial of patients with first-episode mania stabilised on a combination of lithium and quetiapine, subsequently randomised to lithium or quetiapine monotherapy (up to 800 mg/day) and followed up for 1 year. (Trial registration: Australian and New Zealand Clinical Trials Registry - ACTRN12607000639426.) javax.xml.bind.JAXBElement@4e6339d In total, 61 individuals were randomised. Within mixed-model repeated measures analyses, significant omnibus treatment × visit interactions were observed for measures of overall psychopathology, psychotic symptoms and functioning. Planned and javax.xml.bind.JAXBElement@77964a3f comparisons further demonstrated the superiority of lithium treatment over quetiapine. javax.xml.bind.JAXBElement@35b6698f In people with first-episode mania treated with a combination of lithium and quetiapine, continuation treatment with lithium rather than quetiapine is superior in terms of mean levels of symptoms during a 1-year evolution.

Mots-clé
Adolescent, Adult, Antimanic Agents/therapeutic use, Antipsychotic Agents/therapeutic use, Bipolar Disorder/diagnosis, Bipolar Disorder/drug therapy, Drug Therapy, Combination, Female, Humans, Lithium Compounds/therapeutic use, Male, Quality of Life, Quetiapine Fumarate/therapeutic use, Single-Blind Method, Treatment Outcome, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/03/2017 18:32
Dernière modification de la notice
20/08/2019 14:04
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