Postnatal disappearance of self-reactive (V beta 6+) cells from the thymus of Mlsa mice. Implications for T cell development and autoimmunity

Details

Serval ID
serval:BIB_2545682AF08A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Postnatal disappearance of self-reactive (V beta 6+) cells from the thymus of Mlsa mice. Implications for T cell development and autoimmunity
Journal
Journal of Experimental Medicine
Author(s)
Schneider  R., Lees  R. K., Pedrazzini  T., Zinkernagel  R. M., Hengartner  H., MacDonald  H. R.
ISSN
0022-1007 (Print)
Publication state
Published
Issued date
06/1989
Volume
169
Number
6
Pages
2149-58
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jun 1
Abstract
The postnatal ontogeny of potentially autoreactive T cells has been studied in a model system where a particular TCR beta chain variable domain (V beta 6) is correlated with reactivity to a minor antigen encoded by the Mlsa locus. Although absent among mature (CD4+ or CD8+) T cells in adult mice expressing Mlsa, brightly staining V beta 6+ cells were readily detectable in the thymus of neonatal animals, reaching a maximum after 4 d and decreasing rapidly thereafter. These V beta 6+ thymocytes were predominantly of the CD4+ phenotype and were localized in the medulla of the developing thymus. Furthermore, the intensity of TCR expression by these CD4+ cells was significantly (twofold) reduced as compared with age-matched Mlsb controls. A rapid disappearance of CD4+V beta 6+ cells (and corresponding decrease in TCR density) could also be observed in the thymus of Mlsb mice that had been injected neonatally with Mlsa spleen cells. Taken together, these results raise the possibility that some autoreactive T cells may persist after birth and that TCR downregulation may occur as a physiological response to tolerogenic signals in vivo.
Keywords
Animals Animals, Newborn/growth & development/*immunology Autoimmune Diseases/*immunology Cell Differentiation Frozen Sections Immunization, Passive *Immunoglobulin Variable Region/analysis Lymph Nodes/analysis/growth & development Lymphocyte Activation Mice Mice, Inbred BALB C Phenotype *Receptors, Antigen, T-Cell/analysis Receptors, Antigen, T-Cell, alpha-beta Spleen/transplantation Staining and Labeling T-Lymphocytes/classification/immunology/*physiology Thymus Gland/analysis/growth & development
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 8:45
Last modification date
20/08/2019 13:03
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