Nouveaux médicaments dans le cancer bronchique [New drugs in bronchial cancer].

Details

Serval ID
serval:BIB_25387
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nouveaux médicaments dans le cancer bronchique [New drugs in bronchial cancer].
Journal
Presse Médicale
Author(s)
Delbaldo C., Faivre S., Monnerat C., Le Chevalier T.
ISSN
0755-4982 (Print)
ISSN-L
0755-4982
Publication state
Published
Issued date
2002
Volume
31
Number
17
Pages
802-809
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Review
Publication Status: ppublish
Abstract
MODEST RESULTS TILL NOW: Despite progress in the treatment of bronchial cancer (BC) over the last 20 years, notably with platinum-based chemotherapy, results in terms of survival have been modest and prognosis of the tumor generally remains unfavorable. CLASSICAL CHEMOTHERAPY: In non-small cell BC, 5 new cytotoxic agents: vinorelbine (a new mitotic inhibitor), gemcitabine (an antimetabolic), docetaxel and paclitaxel (of the taxane family), irinotecan (DNA repair enzyme inhibitor) have shown interesting results. In small cell BC, among the new cytotoxics, only topoisomerase I inhibitors represented by irinotecan and topotecan are really interesting. Taxanes appear rather disappointing. ONGOING CLINICAL ASSESSMENT OF NEW MOLECULES: Exploration of new drugs is an absolute priority. In parallel with the development of new traditional cytotoxics (trapazamin, oxaliplatin, ALIMTA a new antifolate, UFT and epothilone); studies on agents with biological or molecular effects: thyroxin-kinase inhibitors, trastuzumab--a monoclonal antibody--a metalloprotease inhibitor and marimastat are presently ongoing.
Keywords
Antimetabolites, Antineoplastic/therapeutic use, Antineoplastic Agents/classification, Antineoplastic Agents/therapeutic use, Carcinoma, Non-Small-Cell Lung/drug therapy, Deoxycytidine/analogs & derivatives, Deoxycytidine/therapeutic use, Drug Therapy/trends, Humans, Lung Neoplasms/drug therapy, Vinblastine/analogs & derivatives, Vinblastine/therapeutic use
Pubmed
Web of science
Create date
19/11/2007 12:21
Last modification date
20/08/2019 13:03
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