Influenza vaccination and humoral alloimmunity in solid organ transplant recipients.

Détails

ID Serval
serval:BIB_252EB74C8343
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Influenza vaccination and humoral alloimmunity in solid organ transplant recipients.
Périodique
Transplant International
Auteur(s)
Vermeiren P., Aubert V., Sugamele R., Aubert J.D., Venetz J.P., Meylan P., Pascual M., Manuel O.
ISSN
1432-2277 (Electronic)
ISSN-L
0934-0874
Statut éditorial
Publié
Date de publication
2014
Volume
27
Numéro
9
Pages
903-908
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Annual influenza vaccination is recommended in solid organ transplant (SOT) recipients. However, concerns have been raised about the impact of vaccination on antigraft alloimmunity. We evaluated the humoral alloimmune responses to influenza vaccination in a cohort of SOT recipients between October 2008 and December 2011. Anti-HLA antibodies were measured before and 4-8 weeks after influenza vaccination using a solid-phase assay. Overall, 169 SOT recipients were included (kidney = 136, lung = 26, liver = 3, and combined = 4). Five (2.9%) of 169 patients developed de novo anti-HLA antibodies after vaccination, including one patient who developed donor-specific antibodies (DSA) 8 months after vaccination. In patients with pre-existing anti-HLA antibodies, median MFI was not significantly different before and after vaccination (P = 0.73 for class I and P = 0.20 for class II anti-HLA antibodies) and no development of de novo DSA was observed. Five episodes of rejection (2.9%) were observed within 12 months after vaccination, and only one patient had de novo anti-HLA antibodies. The incidence of development of anti-HLA antibodies after influenza vaccination in our cohort of SOT recipients was very low. Our findings indicate that influenza vaccination is safe and does not trigger humoral alloimmune responses in SOT recipients.
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/09/2014 16:39
Dernière modification de la notice
20/08/2019 13:03
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