Extraosseous langerhans cell histiocytosis in children

Détails

ID Serval
serval:BIB_24942265651E
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Extraosseous langerhans cell histiocytosis in children
Périodique
Radiographics
Auteur(s)
Schmidt S., Eich G., Geoffray A., Hanquinet S., Waibel P., Wolf R., Letovanec I., Alamo-Maestre L., Gudinchet F.
ISSN
1527-1323
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
28
Numéro
3
Pages
707-726; quiz 910-911
Langue
anglais
Résumé
Langerhans cell histiocytosis, a rare disease that occurs mainly in children, may produce a broad range of manifestations, from a single osseous lesion to multiple lesions involving more than one organ or system. The clinical course varies widely in relation to the patient's age. Multisystem disease may demonstrate especially aggressive behavior in very young children, with the outcome depending largely on the stage of disease and the degree of related organ dysfunction at the time of diagnosis. Extraosseous manifestations are less commonly seen than osseous ones and may be more difficult to identify. To accurately detect extraosseous Langerhans cell histiocytosis at an early stage, radiologists must recognize the significance of individual clinical and laboratory findings as well as the relevance of imaging features for the differential diagnosis. The pattern and severity of pulmonary, thymic, hepatobiliary, splenic, gastrointestinal, neurologic, mucocutaneous, soft-tissue (head and neck), and salivary involvement in Langerhans cell histiocytosis generally are well depicted with conventional radiography, ultrasonography, computed tomography, and magnetic resonance imaging. However, the imaging features are not pathognomonic, and a biopsy usually is necessary to establish a definitive diagnosis.
Mots-clé
Child, Preschool, Diagnostic Imaging, Female, Histiocytosis, Langerhans-Cell, Humans, Image Enhancement, Male, Multiple Organ Failure
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/06/2008 11:32
Dernière modification de la notice
20/08/2019 14:02
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