MIMAS 3.0 is a Multiomics Information Management and Annotation System.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_2455DAB29335
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
MIMAS 3.0 is a Multiomics Information Management and Annotation System.
Périodique
BMC Bioinformatics
Auteur(s)
Gattiker A., Hermida L., Liechti R., Xenarios I., Collin O., Rougemont J., Primig M.
ISSN
1471-2105 (Electronic)
ISSN-L
1471-2105
Statut éditorial
Publié
Date de publication
2009
Volume
10
Pages
151
Langue
anglais
Résumé
BACKGROUND: DNA sequence integrity, mRNA concentrations and protein-DNA interactions have been subject to genome-wide analyses based on microarrays with ever increasing efficiency and reliability over the past fifteen years. However, very recently novel technologies for Ultra High-Throughput DNA Sequencing (UHTS) have been harnessed to study these phenomena with unprecedented precision. As a consequence, the extensive bioinformatics environment available for array data management, analysis, interpretation and publication must be extended to include these novel sequencing data types.
DESCRIPTION: MIMAS was originally conceived as a simple, convenient and local Microarray Information Management and Annotation System focused on GeneChips for expression profiling studies. MIMAS 3.0 enables users to manage data from high-density oligonucleotide SNP Chips, expression arrays (both 3'UTR and tiling) and promoter arrays, BeadArrays as well as UHTS data using MIAME-compliant standardized vocabulary. Importantly, researchers can export data in MAGE-TAB format and upload them to the EBI's ArrayExpress certified data repository using a one-step procedure.
CONCLUSION: We have vastly extended the capability of the system such that it processes the data output of six types of GeneChips (Affymetrix), two different BeadArrays for mRNA and miRNA (Illumina) and the Genome Analyzer (a popular Ultra-High Throughput DNA Sequencer, Illumina), without compromising on its flexibility and user-friendliness. MIMAS, appropriately renamed into Multiomics Information Management and Annotation System, is currently used by scientists working in approximately 50 academic laboratories and genomics platforms in Switzerland and France. MIMAS 3.0 is freely available via http://multiomics.sourceforge.net/.
Mots-clé
Abstracting and Indexing as Topic/methods, Database Management Systems, Databases, Genetic, Genomics/methods, Information Storage and Retrieval/methods, Internet, Oligonucleotide Array Sequence Analysis, Software
Pubmed
Web of science
Open Access
Oui
Création de la notice
17/10/2012 12:05
Dernière modification de la notice
20/08/2019 13:02
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