Article: article from journal or magazin.
Granules of cytolytic T-lymphocytes contain two serine esterases
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jul
Cytoplasmic granules from cytolytic T-lymphocytes (CTL) contain two proteins which react with the serine esterase-specific affinity label diisopropylfluorophosphate (DFP). One of these is a trypsin-like esterase which consists of two disulfide-linked 35-kd subunits. The other consists of a single 29-kd chain. Both molecules are induced concomitantly with cytolytic activity and perforin activity in a CTL-derived T-cell hybrid.
Animals Cell Line Cytoplasmic Granules/*enzymology Esterases/isolation & purification/*metabolism Hemolysis Hydrogen-Ion Concentration Isoflurophate/pharmacology Kinetics Mice T-Lymphocytes, Cytotoxic/*immunology
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