Nicotine replacement to reduce cigarette consumption in smokers who are unwilling to quit: a randomized trial.

Details

Serval ID
serval:BIB_24276
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nicotine replacement to reduce cigarette consumption in smokers who are unwilling to quit: a randomized trial.
Journal
Journal of Clinical Psychopharmacology
Author(s)
Etter J.F., Laszlo E., Zellweger J.P., Perrot C., Perneger T.V.
ISSN
0271-0749 (Print)
ISSN-L
0271-0749
Publication state
Published
Issued date
2002
Volume
22
Number
5
Pages
487-495
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The objective of this study was to assess whether nicotine replacement therapy, administered in a real-life situation, could reduce cigarette consumption in smokers who were not prepared to quit smoking. Daily smokers of more than 20 cigarettes per day who had no intention to quit smoking in the next 6 months were recruited from the general population and randomly assigned to either a 6-month treatment of nicotine (choice among a 15-mg nicotine patch, a 4-mg nicotine gum, a 10-mg nicotine inhaler, or a combination of these, N = 265), matching placebo products (N = 269), or no intervention (N = 389). Products were sent to participants by mail. Education was limited to a booklet. Of 923 participants, 879 (95%) were followed up after 6 months. Mean baseline consumption was 30 cigarettes per day in all groups. At 6 months, cigarette consumption decreased by a median of 10 cigarettes per day in the nicotine group, 7.5 in the placebo group, and 2.5 among controls ( < 0.04 for all pair-wise comparisons). Smoking cessation rates were low (2%-4%) and did not differ significantly between groups. Quit attempts were less frequent among controls (21%) than among the nicotine (28%, = 0.04) and placebo (27%, = 0.08) subjects. In conclusion, nicotine replacement therapy helped smokers reduce their cigarette consumption and maintain this reduction over 6 months, but a large part of this reduction was attributable to a placebo effect. Nicotine treatment for smoking reduction had no detectable impact on smoking cessation.
Keywords
Administration, Cutaneous, Administration, Inhalation, Administration, Oral, Adult, Female, Humans, Male, Middle Aged, Nicotine/administration & dosage, Nicotine/therapeutic use, Nicotinic Agonists/administration & dosage, Nicotinic Agonists/therapeutic use, Smoking Cessation, Tobacco Use Disorder/drug therapy, Treatment Failure
Pubmed
Web of science
Create date
19/11/2007 12:20
Last modification date
20/08/2019 13:02
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