B-cell development and differentiation

Details

Serval ID
serval:BIB_240D0FEA6272
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
B-cell development and differentiation
Journal
Seminars in Hematology
Author(s)
Duchosal  M. A.
ISSN
0037-1963 (Print)
Publication state
Published
Issued date
01/1997
Volume
34
Number
1 Suppl 1
Pages
2-12
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Jan
Abstract
B-cell development is characterized by antigen-independent phases in fetal hematopoietic organs and adult bone marrow, which lead to naive recirculating B cells in the periphery. The diversity of the naive (primary) B-cell repertoire resides in somatic events where minigenes from a large available repertoire are imprecisely rearranged and encode antigen-binding sites of antibodies. Naive B cells expand upon antigenic stimulation, acquire somatic mutations leading to high-affinity antibodies, and switch immunoglobulin (Ig) isotype in peripheral lymphoid organs. This immune reaction leads to the generation of memory B cells, which are long-lived and capable of rapid generation of specific high-affinity antibodies upon recall antigenic stimulation, as well as plasma cells, which constitutively secrete a large amount of antibodies.
Keywords
Antigens, Differentiation/immunology B-Lymphocytes/*cytology Cell Aging/physiology Cell Differentiation/physiology Embryonic and Fetal Development/immunology Humans *Lymphocyte Activation Receptors, Antigen, B-Cell/*immunology Stem Cells/*cytology
Pubmed
Web of science
Create date
25/01/2008 15:24
Last modification date
20/08/2019 13:01
Usage data