Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouse.

Détails

ID Serval
serval:BIB_23D97F418B4A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Intestinal intraepithelial lymphocyte gamma delta-T cell-derived keratinocyte growth factor modulates epithelial growth in the mouse.
Périodique
Journal of Immunology
Auteur(s)
Yang H., Antony P.A., Wildhaber B.E., Teitelbaum D.H.
ISSN
0022-1767 (Print)
ISSN-L
0022-1767
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
172
Numéro
7
Pages
4151-4158
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. Publication Status: ppublish
Résumé
Keratinocyte growth factor (KGF) promotes intestinal epithelial growth. To understand the relevance of intraepithelial lymphocyte (IEL)-derived KGF expression on epithelial growth, we used a mouse model of villus atrophy by the administration of total parenteral nutrition, and a model of villus hypertrophy by the creation of a short bowel syndrome. KGF expression was confined to gammadelta-TCR(+) IELs. IEL-derived KGF expression was highest in the crypts, somewhat less in the lower portion of villi, and markedly lower in the upper portion of villi. Total parenteral nutrition administration was associated with a down-regulation of IEL-derived KGF expression, and short bowel syndrome was associated with an up-regulation of IEL-derived KGF expression. In the absence of gammadelta-TCR(+) IEL, using gammadelta(-/-) mice, intestinal epithelial cell proliferation decreased in control, and in both mucosal atrophy (22% decline) and mucosal hypertrophy (14%) models. These results show that KGF from IELs is an important factor for maintenance of intestinal epithelial cell proliferation and villus growth.
Mots-clé
Adjuvants, Immunologic/biosynthesis, Adjuvants, Immunologic/physiology, Animals, Atrophy, Cell Division/genetics, Cell Division/immunology, Fibroblast Growth Factor 7, Fibroblast Growth Factors/biosynthesis, Fibroblast Growth Factors/physiology, Hypertrophy, Intestinal Mucosa/cytology, Intestinal Mucosa/immunology, Jejunum/immunology, Jejunum/metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Microdissection/methods, Microvilli/pathology, Parenteral Nutrition, Total, Receptors, Antigen, T-Cell, gamma-delta/biosynthesis, Receptors, Antigen, T-Cell, gamma-delta/deficiency, Short Bowel Syndrome/genetics, Short Bowel Syndrome/immunology, T-Lymphocyte Subsets/immunology, T-Lymphocyte Subsets/metabolism
Pubmed
Web of science
Création de la notice
21/02/2015 14:19
Dernière modification de la notice
03/03/2018 14:55
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