Article: article from journal or magazin.
Intestinal permeability and inflammation in rheumatoid arthritis: effects of non-steroidal anti-inflammatory drugs
Journal Article --- Old month value: Nov 24
The suggestion that the intestinal mucosa may be abnormally permeable and a site of absorption of antigens in rheumatoid arthritis was tested by the use of a 51Cr-EDTA (edetic acid) absorption test. 24 patients with rheumatoid arthritis excreted significantly more 51Cr-EDTA than did 34 controls. Intestinal permeability was normal in untreated patients but almost invariably abnormal in patients treated with non-steroidal anti-inflammatory drugs. Studies in patients with osteoarthritis showed that the permeability abnormalities were due to an effect of NSAIDs on both the proximal and the distal intestine and that the effect was systemically mediated. Indium-111-labelled leucocyte scans showed ileocaecal inflammation in 6 of 9 patients on or recently on NSAIDs. Although increased intestinal permeability does not seem to be important in the pathogenesis of rheumatoid arthritis, the administration of NSAIDs may lead to loss of intestinal integrity, thus facilitating antigenic absorption and perhaps contributing to persistence of the disease.
Anti-Inflammatory Agents/*therapeutic use Arthritis, Rheumatoid/drug therapy/*metabolism/radionuclide imaging Chromium Radioisotopes/diagnostic use Edetic Acid/diagnostic use Humans Indium/diagnostic use Inflammation/metabolism/radionuclide imaging Intestinal Mucosa/*metabolism/radionuclide imaging Leukocytes Osteoarthritis/drug therapy/metabolism/radionuclide imaging Permeability Radioisotopes/diagnostic use
Web of science
Last modification date